ITIH1
ITIH1 (inter-alpha-trypsin inhibitor heavy chain 1, also known as H1P, IATIH or ITIH) is a secreted member of the ITIH family. Its processed heavy chain forms part of the inter-alpha-trypsin inhibitor complex found in blood and interacts with hyaluronan. Browse Assay Genie's current range of ITIH1 research reagents below, or read on for the biology behind the target.
ITIH1 encodes one of the heavy chains of the inter-alpha-trypsin inhibitor complex. The gene produces a preproprotein that is proteolytically processed to generate the mature heavy chain, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilisation. It has also been implicated in multiple inflammatory diseases.
UniProt annotates the ITIH1 protein as a secreted member of the ITIH family, and notes that it contains a potential peptide that could stimulate a broad spectrum of phagocytic cells. The HGNC places the gene in the group of inter-alpha-trypsin inhibitor heavy chains. Alternative splicing of the ITIH1 gene gives rise to multiple transcript variants, at least one of which encodes the preproprotein described above. The gene lies within a gene cluster on chromosome 3, alongside other ITIH family genes. The mouse ortholog is Itih1.
The protein has been referred to by several names. Aliases include H1P, IATIH and ITIH, and an earlier HGNC name was inter-alpha (globulin) inhibitor, H1 polypeptide. Researchers studying ITIH1 often consider it together with other ITIH heavy chains such as ITIH2, ITIH3, ITIH4 and ITIH5, which belong to the same family.
ITIH1 has been implicated in multiple inflammatory diseases, making it a protein of interest when studying inflammatory processes.
The ITIH1 heavy chain interacts with hyaluronan, a relationship relevant to studies of extracellular matrix interactions.
The interaction of the heavy chain with hyaluronan may play a role in ovulation and fertilisation.
A potential peptide within ITIH1 could stimulate a broad spectrum of phagocytic cells, which invites investigation of innate immune function.
ITIH1 encodes a heavy chain of the inter-alpha-trypsin inhibitor complex, secreted by hepatocytes into the blood. The heavy chain interacts with hyaluronan, which may play a role in ovulation and fertilisation, and it has been implicated in several inflammatory diseases.
ITIH1 is also known as H1P, IATIH and ITIH. The HGNC name is inter-alpha-trypsin inhibitor heavy chain 1, and a previous name was inter-alpha (globulin) inhibitor, H1 polypeptide. UniProt lists it as inter-alpha-trypsin inhibitor heavy chain H1. Alternative splicing produces multiple transcript variants.
The mouse has an ortholog named Itih1, so rodent models can be used to study the gene. ITIH1 sits in a cluster of ITIH family genes on chromosome 3 in humans. Check the datasheet of any product for its validated reactivity.
Other members of the inter-alpha-trypsin inhibitor heavy chain family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P19827; product specifications from Assay Genie datasheets.