STX2
STX2 (syntaxin 2, previously epimorphin) is a membrane-associated member of the syntaxin family, which is implicated in the targeting and fusion of intracellular transport vesicles. It is essential for epithelial morphogenesis and is also known as EPM, EPIM, STX2A, STX2B and STX2C. Browse Assay Genie's current range of STX2 research reagents below, or read on for the biology behind the target.
STX2 is essential for epithelial morphogenesis. According to the NCBI Gene summary, the product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. UniProt also notes that it may mediate Ca(2+)-regulation of exocytosis in the acrosomal reaction in sperm.
The STX2 gene encodes Syntaxin-2, a membrane protein that belongs to the syntaxin/epimorphin family. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles, and HGNC places STX2 in the Syntaxins gene group. Alternatively spliced transcript variants encoding different isoforms have been identified, which is reflected in the aliases STX2A, STX2B and STX2C. Mouse and rat each have an ortholog named Stx2, which allows the protein to be studied in common model systems.
The name epimorphin reflects the role of the protein in epithelial morphogenesis, and EPM and EPIM are further aliases from this history. Researchers working on an STX2 antibody, STX2 ELISA kit or STX2 protein will often study it alongside other syntaxins, such as STX1A, STX3 and STX6, and the syntaxin-binding protein STXBP1, to place it within vesicle trafficking and membrane fusion biology.
STX2 is essential for epithelial morphogenesis, making it a target for studies of how epithelial tissues are shaped.
The STX2 gene product regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation.
As a syntaxin, STX2 belongs to a family implicated in the targeting and fusion of intracellular transport vesicles.
STX2 may mediate Ca(2+)-regulation of exocytosis in the sperm acrosomal reaction, a topic in reproductive cell biology.
STX2 is essential for epithelial morphogenesis and regulates epithelial-mesenchymal interactions and epithelial cell activation. As a syntaxin, it belongs to a family implicated in vesicle targeting and fusion. It may also mediate Ca(2+)-regulation of exocytosis in the sperm acrosomal reaction.
Epimorphin is the previous name of the gene, and the family is described as the syntaxin/epimorphin family. Other aliases include EPM, EPIM, STX2A, STX2B and STX2C. Alternatively spliced transcript variants encoding different isoforms have been identified, so check which isoform a reagent targets.
Yes. Mouse and rat both have an ortholog called Stx2, so the protein can be studied in these common model species. Cross-species use depends on the reagent, so check the datasheet of any product for its validated reactivity.
Other syntaxins and syntaxin-binding proteins involved in vesicle trafficking and membrane fusion.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P32856; product specifications from Assay Genie datasheets.