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Anti-STX2 Antibody (CAB10444)

SKU:
CAB10444
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 1 Anti-STX2 Antibody CAB10444
  • Cell Biology Antibodies 1 Anti-STX2 Antibody CAB10444
€139 - €419
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Description

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Antibody Name:Anti-STX2 Antibody
Antibody SKU:CAB10444
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human STX2 (NP_001971.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, DU145, SKOV3, A-549, Mouse heart, Mouse testis, Rat liver, Rat heart, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human STX2 (NP_001971.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MRDR LPDL TACR KNDD GDTV VVVE KDHF MDDF FHQV EEIR NSID KITQ YVEE VKKN HSII LSAP NPEG KIKE ELED LNKE IKKT ANKI RAKL KAIE QSFD QDES GNRT SVDL RIRR TQHS VLSR KFVE AMAE YNEA QTLF RERS KGRI QRQL EITG RTTT DDEL EEML ESGK PSIF TSDI ISDS QITR QALN EIES RHKD IMKL ETSI RELH EMFM DMAM FVET QGEM INNI ERNV MNAT DYVE HAKE ETKK AIKY QSKA RRKL
Gene ID:2054
Uniprot:P32856
Cellular Location:Membrane, Single-pass type IV membrane protein
Calculated MW:32kDa/33kDa
Observed MW:36kDa
Synonyms:STX2, EPIM, EPM, STX2A, STX2B, STX2C
Background:The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniProt Protein Function:STX2: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: basolateral plasma membrane; extracellular space; integral to membrane; intracellular membrane-bound organelle; lamellipodium; plasma membrane; SNARE complex; synaptic vesicle

Molecular Function:calcium-dependent protein binding; protein binding; protein dimerization activity; SNAP receptor activity; SNARE binding

Biological Process: acrosome reaction; ectoderm development; intracellular protein transport; organ morphogenesis; protein oligomerization; regulation of blood coagulation; response to hydroperoxide; signal transduction; synaptic vesicle fusion to presynaptic membrane; vesicle docking

NCBI Summary:The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:P32856
NCBI GenInfo Identifier:292495060
NCBI Gene ID:2054
NCBI Accession:P32856.3
UniProt Secondary Accession:P32856,Q86VW8,
UniProt Related Accession:P32856
Molecular Weight:32,425 Da
NCBI Full Name:Syntaxin-2
NCBI Synonym Full Names:syntaxin 2
NCBI Official Symbol:STX2  
NCBI Official Synonym Symbols:EPM; EPIM; STX2A; STX2B; STX2C  
NCBI Protein Information:syntaxin-2
UniProt Protein Name:Syntaxin-2
UniProt Synonym Protein Names:Epimorphin
Protein Family:Syntaxin
UniProt Gene Name:STX2  
UniProt Entry Name:STX2_HUMAN
Anti-STX2 Antibody (CAB10444)Western blot analysis of extracts of various cell lines, using STX2 antibody (CAB10444) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-STX2 Antibody (CAB10444)Immunofluorescence analysis of NIH/3T3 cells using STX2 antibody (CAB10444) at dilution of 1:100. Blue: DAPI for nuclear staining.

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