TTLL12
TTLL12 (tubulin tyrosine ligase like 12, also known as KIAA0153) is a member of the tubulin tyrosine ligase family. It negatively regulates post-translational modifications of tubulin, contributes to mitosis and chromosome stability, and restrains RIG-I signalling during RNA virus infection. Browse Assay Genie's current range of TTLL12 research reagents below, or read on for the biology behind the target.
TTLL12 is a negative regulator of post-translational modifications of tubulin. According to UniProt, it suppresses both detyrosination of the tubulin C-terminus and polyglutamylation of glutamate residues. It also indirectly promotes trimethylation of histone H4 at Lys-20 (H4K20me3), and NCBI Gene describes it as enabling histone H4K20me2 reader activity. Probably by controlling tubulin and/or histone H4 modifications, the TTLL12 protein plays a role in mitosis and in maintaining chromosome number stability.
TTLL12 has a second, separate role in innate immunity. During RNA virus-mediated infection it acts as a negative regulator of the RIG-I pathway by preventing MAVS from binding to TBK1 and IKBKE. This is consistent with the NCBI Gene annotation, which links the gene to negative regulation of type I interferon-mediated signalling and to regulation of the mitotic cell cycle.
The TTLL12 gene belongs to the tubulin tyrosine ligase family, and the protein is also listed under the previous name tubulin tyrosine ligase-like family member 12 and the alias KIAA0153. UniProt reports it in the cytoplasm, midbody, centrosome, spindle and nucleus, and NCBI Gene places it in the cytosol and nucleoplasm. The mouse ortholog is Ttll12. These locations match its dual involvement in cytoskeletal and chromatin-related processes.
TTLL12 is implicated in mitosis and in maintaining chromosome number stability, probably through control of tubulin and histone H4 modifications.
TTLL12 negatively regulates tubulin detyrosination and polyglutamylation, making it relevant to studies of the tubulin modification landscape.
TTLL12 blocks MAVS binding to TBK1 and IKBKE, negatively regulating the RIG-I pathway during RNA virus infection.
TTLL12 indirectly promotes H4K20me3 and is annotated as an H4K20me2 reader, linking it to chromatin regulation.
TTLL12 negatively regulates tubulin detyrosination and polyglutamylation, and indirectly promotes histone H4 Lys-20 trimethylation. It contributes to mitosis and chromosome number stability. During RNA virus infection it also dampens RIG-I signalling by preventing MAVS binding to TBK1 and IKBKE.
The HGNC full name is tubulin tyrosine ligase like 12, and UniProt lists tubulin--tyrosine ligase-like protein 12. The previous symbol is KIAA0153, and an earlier name was tubulin tyrosine ligase-like family member 12. Use these terms when searching the literature.
A mouse ortholog, Ttll12, is recorded for the human gene. TTLL12 belongs to the tubulin tyrosine ligase family. Cross-species use depends on the reagent, so check the datasheet of any product for its validated reactivity.
Tubulin-modifying enzymes, RIG-I pathway components and chromatin-related targets connected to TTLL12 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14166; product specifications from Assay Genie datasheets.