MC5R
MC5R (melanocortin 5 receptor) is a seven-pass transmembrane G protein-coupled receptor for melanocyte-stimulating hormones and corticotropin (ACTH). It belongs to the melanocortin receptor group and signals through cAMP, with roles in immune response, temperature regulation and exocrine gland function. Browse Assay Genie's current range of MC5R research reagents below, or read on for the biology behind the target.
MC5R is a G protein-coupled receptor for alpha-, beta- and gamma-melanocyte-stimulating hormone (MSH) and for corticotropin/ACTH, all of which are peptide products of the POMC precursor. On activation it couples to G(s) protein, which stimulates adenylate cyclase and the cAMP-dependent signalling pathway. It also activates ERK1/2 through a PI3K-dependent mechanism. Among the natural melanocortins, the order of potency for receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH.
The MC5R gene encodes a seven-pass transmembrane protein that sits in the cell membrane. The human receptor is catalogued as melanocortin receptor 5 in UniProt and belongs to the G protein-coupled receptor 1 family. HGNC places it in the melanocortin receptors gene group, alongside family members such as MC1R and MC4R. Mouse and rat both carry an orthologous Mc5r gene, so the receptor can be studied in common rodent models.
Functionally, MC5R plays a key role in immune response and is essential for temperature regulation and exocrine gland function. The NCBI Gene summary also suggests a role in sebum generation. These features make the MC5R protein a point of interest for researchers studying melanocortin signalling outside the pigmentation and energy-balance contexts usually associated with other receptors in the group.
MC5R responds to MSH and ACTH peptides derived from POMC, making it a model for studying ligand potency and receptor selectivity within the melanocortin family.
Activation of MC5R couples to G(s), adenylate cyclase and cAMP, and also engages ERK1/2 through a PI3K-dependent route.
MC5R is reported to play a key role in immune response, supporting investigation of melanocortin receptors in immune regulation.
MC5R is essential for exocrine gland function and is suggested to play a role in sebum generation, as well as temperature regulation.
MC5R is a G protein-coupled receptor for alpha-, beta- and gamma-MSH and ACTH. It couples to G(s), stimulating adenylate cyclase and cAMP signalling, and can activate ERK1/2 via PI3K. It plays a key role in immune response and is essential for temperature regulation and exocrine gland function.
MC5R stands for melanocortin 5 receptor, and UniProt lists the protein as melanocortin receptor 5. HGNC records no alias symbols or previous names. It sits in the melanocortin receptors gene group, together with related receptors such as MC1R and MC4R.
Yes. Both mouse and rat have an orthologous gene named Mc5r, so rodent models can be used to study the receptor's roles in immune response, temperature regulation and exocrine function. Check the datasheet of any product for its validated reactivity.
Other melanocortin receptors and related G protein-coupled receptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P33032; product specifications from Assay Genie datasheets.