PSG6
PSG6 (pregnancy specific beta-1-glycoprotein 6) is a secreted member of the pregnancy-specific glycoprotein family, a subgroup of the carcinoembryonic antigen (CEA) family within the immunoglobulin superfamily. The PSG6 gene is expressed by placental trophoblasts, and its product is released into the maternal circulation during pregnancy. Browse Assay Genie's current range of PSG6 research reagents below, or read on for the biology behind the target.
PSG6 is a pregnancy-specific glycoprotein produced by placental trophoblasts and released into the maternal circulation during pregnancy. The PSG family is thought to be essential for the maintenance of normal pregnancy. The PSG6 protein is secreted, and it belongs to the immunoglobulin superfamily and the CEA family. No detailed molecular mechanism is described in the sources used for this page.
The PSG6 gene is one of the pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes. These genes sit together in a cluster at 19q13.1-q13.2, telomeric to another cluster of CEA-related genes. HGNC classifies PSG6 in the V-set domain containing group and in the pregnancy specific glycoproteins group. The encoded protein contains the Arg-Gly-Asp (RGD) tripeptide, a motif associated with cellular adhesion and recognition. Alternative splicing of the PSG6 gene results in multiple transcript variants and protein isoforms.
Researchers studying placental biology, trophoblast secretion and maternal-foetal signalling use the PSG6 protein and its relatives as markers of the pregnancy-specific glycoprotein family. Because PSG family members are closely related, work on PSG6 is often considered alongside other PSG genes such as PSG1, PSG2, PSG3 and PSG11.
PSG genes are expressed by placental trophoblasts, making PSG6 relevant to studies of placental gene expression and function.
PSG products are released into the maternal circulation during pregnancy, so PSG6 is of interest for work on secreted pregnancy-associated proteins.
The PSG family is thought to be essential for maintaining normal pregnancy, which motivates investigation of individual members such as PSG6.
The encoded protein contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition, a feature relevant to adhesion-focused studies.
PSG6 is a secreted glycoprotein expressed by placental trophoblasts and released into the maternal circulation during pregnancy. The PSG family is thought to be essential for maintaining normal pregnancy. PSG6 also carries an Arg-Gly-Asp tripeptide, a motif associated with cellular adhesion and recognition.
The HGNC full name is pregnancy specific beta-1-glycoprotein 6, and no aliases or previous symbols are listed. Alternative splicing of the PSG6 gene results in multiple transcript variants and protein isoforms, so check which isoform an assay is expected to detect.
PSG6 belongs to the pregnancy-specific glycoprotein gene family, a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes. The genes cluster at 19q13.1-q13.2. Related members include PSG1, PSG2, PSG3 and PSG11; check the datasheet of any product for its validated reactivity.
Other pregnancy-specific glycoproteins from the same CEA-related gene cluster with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q00889; product specifications from Assay Genie datasheets.