SCGB1D2
SCGB1D2 (secretoglobin family 1D member 2) is a secreted member of the lipophilin subfamily of the secretoglobin family. It is also known as LPHB and LIPB, and is proposed to bind androgens and other steroids. Browse Assay Genie's current range of SCGB1D2 research reagents below, or read on for the biology behind the target.
SCGB1D2 is a secreted protein that may bind androgens and other steroids. It may also bind estramustine, a chemotherapeutic agent used for prostate cancer. These functions are described as putative: they are inferred from its relationship to prostatein, the major secretory glycoprotein of the rat ventral prostate gland, rather than being fully established. The source annotation also suggests that SCGB1D2 may be under the transcriptional regulation of steroid hormones.
The SCGB1D2 gene encodes a member of the lipophilin subfamily, which belongs to the secretoglobin family and the wider uteroglobin superfamily. The protein is an ortholog of prostatein. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. If human lipophilins are the functional counterparts of prostatein, they may be regulated by steroid hormones and may bind and concentrate estramustine. The rat ortholog is listed as Psbpc1.
The gene has the aliases LPHB and LIPB. It was once reported to lie on chromosome 10, but the sequence appears to come from a cluster of genes on chromosome 11 that includes mammaglobin 2. This cluster relationship places SCGB1D2 alongside other secretoglobin genes such as SCGB2A2 (mammaglobin A) and SCGB3A2, which are useful comparators when studying the family.
SCGB1D2 may bind androgens and other steroids, making it a candidate for studying secreted steroid-binding proteins.
Lipophilin gene products are widely expressed in normal tissues, especially endocrine-responsive organs, which frames studies of hormone-regulated expression.
The protein may bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer, which is relevant to drug-binding studies.
As a lipophilin subfamily member of the uteroglobin superfamily, SCGB1D2 supports comparative work across secretoglobins and the prostatein ortholog.
SCGB1D2 is a secreted protein that may bind androgens and other steroids, and possibly estramustine, a chemotherapeutic agent used for prostate cancer. It may also be transcriptionally regulated by steroid hormones. These roles are inferred from its relationship to rat prostatein and remain putative.
The HGNC name is secretoglobin family 1D member 2, and the aliases are LPHB and LIPB. The protein belongs to the lipophilin subfamily of the secretoglobin family, which is part of the uteroglobin superfamily. It is an ortholog of rat prostatein.
SCGB1D2 is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. The rat ortholog is listed as Psbpc1, and no mouse ortholog is given in the data. Check the datasheet of any product for its validated reactivity.
Other secretoglobin family members that sit alongside SCGB1D2 in the same gene cluster or superfamily.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95969; product specifications from Assay Genie datasheets.