GDA
GDA (guanine deaminase) is an enzyme that catalyses the hydrolytic deamination of guanine, producing xanthine and ammonia. The protein is also known as CYPIN and GAH, and studies of the rat ortholog link it to microtubule assembly. Browse Assay Genie's current range of GDA research reagents below, or read on for the biology behind the target.
GDA catalyses the hydrolytic deamination of guanine, producing xanthine and ammonia. This reaction removes guanine from the free purine pool and converts it into xanthine, so the enzyme sits within purine catabolism. It is classified under EC 3.5.4.3 as a guanine deaminase, and researchers studying nucleotide turnover often examine the GDA protein alongside other purine-processing enzymes.
The human GDA gene encodes a protein of the metallo-dependent hydrolases superfamily, in the ATZ/TRZ family. HGNC places it in the M38 metallopeptidases gene group. The gene is located at 9q21.13, and multiple transcript variants encoding different isoforms have been reported. The mouse and rat orthologs are both named Gda, which allows comparative work in rodent systems. UniProt does not currently annotate a subcellular location for the protein.
Besides its catalytic role, the gene has a second line of interest. Studies in the rat ortholog suggest that it plays a role in microtubule assembly, which is reflected in the alias CYPIN. The other alias, GAH, reflects the enzyme activity. Together these names mark GDA as a protein studied both as a metabolic enzyme and in relation to the cytoskeleton.
GDA converts guanine to xanthine and ammonia through hydrolytic deamination, making it a point of study in purine catabolism.
As a member of the metallo-dependent hydrolases superfamily, ATZ/TRZ family, GDA is a subject for studies of hydrolytic deaminase mechanism.
Studies of the rat ortholog suggest a role in microtubule assembly, prompting research into how GDA relates to cytoskeletal biology.
Multiple transcript variants encoding different isoforms exist for the GDA gene, which makes isoform-level expression a topic of investigation.
GDA, or guanine deaminase, catalyses the hydrolytic deamination of guanine, producing xanthine and ammonia. It is assigned EC 3.5.4.3. Studies in the rat ortholog also suggest that the gene plays a role in microtubule assembly.
GDA is also known as CYPIN and GAH, and its HGNC name is guanine deaminase. NCBI Gene reports that multiple transcript variants of the gene encode different isoforms. Check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat both carry a Gda ortholog of the human gene. The rat ortholog has been used in studies suggesting a role for the gene in microtubule assembly. Check the datasheet of any product for its validated reactivity.
Other purine metabolism enzymes and cytoskeleton-associated targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y2T3; product specifications from Assay Genie datasheets.