CDC25A
CDC25A (cell division cycle 25A) is a tyrosine protein phosphatase, also called M-phase inducer phosphatase 1, that drives cell cycle progression by activating cyclin-dependent kinases. It is a member of the CDC25 phosphatase family and is classed as an oncogene. Browse Assay Genie's current range of CDC25A research reagents below, or read on for the biology behind the target.
CDC25A is a tyrosine protein phosphatase that functions as a dosage-dependent inducer of mitotic progression. It directly dephosphorylates CDK1 and stimulates its kinase activity. NCBI describes the same action as activation of the cyclin-dependent kinase CDC2 through removal of two phosphate groups. UniProt also reports that CDC25A dephosphorylates CDK2 in complex with cyclin-E in vitro. CDC25A is required for progression from the G1 phase into S phase of the cell cycle.
The human CDC25A gene encodes a 524-amino-acid protein that belongs to the MPI phosphatase family. HGNC places it in the Class III Cys-based CDC25 phosphatases, alongside CDC25B and CDC25C. Mouse and rat both carry a Cdc25a ortholog. Two transcript variants encoding different isoforms have been described for the gene. UniProt does not annotate a subcellular location for the protein.
CDC25A is specifically degraded in response to DNA damage. This prevents cells with chromosomal abnormalities from progressing through cell division, so the protein links checkpoint signalling to the cell cycle machinery. CDC25A is recognised as an oncogene, although NCBI notes that its exact role in oncogenesis has not been demonstrated. Researchers studying CDC25A, whether through an CDC25A antibody, an CDC25A ELISA kit or recombinant CDC25A protein, usually work in cell cycle control, checkpoint biology and cancer research.
CDC25A is required for the G1 to S transition and acts as a dosage-dependent inducer of mitotic progression.
CDC25A dephosphorylates CDK1 and stimulates its kinase activity, and dephosphorylates CDK2 in complex with cyclin-E in vitro.
CDC25A is specifically degraded after DNA damage, preventing cells with chromosomal abnormalities from progressing through division.
CDC25A is classed as an oncogene, though its exact role in oncogenesis has not yet been demonstrated.
CDC25A is a tyrosine protein phosphatase that induces mitotic progression in a dosage-dependent manner. It dephosphorylates CDK1 and stimulates its kinase activity. It is also required for the G1 to S phase transition. Check the datasheet of any product for its validated reactivity.
UniProt names the protein M-phase inducer phosphatase 1, and HGNC names the gene cell division cycle 25A. No other aliases or previous symbols are listed. NCBI reports two transcript variants for the gene, which encode different isoforms.
Mouse and rat each have a Cdc25a ortholog. NCBI describes CDC25A as an oncogene, although its exact role in oncogenesis has not been demonstrated. Its degradation after DNA damage helps stop cells with chromosomal abnormalities from dividing.
Other CDC25 phosphatases and cell division cycle proteins involved in cell cycle control.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P30304; product specifications from Assay Genie datasheets.