MAP3K11
MAP3K11 (mitogen-activated protein kinase kinase kinase 11, also known as MLK3, SPRK, MEKK11 and PTK1) is a serine/threonine kinase that activates the JUN N-terminal pathway. It acts upstream of the MAP2K4 and MAP2K7 kinases and is a positive regulator of JNK signalling. Browse Assay Genie's current range of MAP3K11 research reagents below, or read on for the biology behind the target.
MAP3K11 is a serine/threonine kinase that sits at the top of mitogen-activated protein kinase cascades. It is required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). It does this by phosphorylating and activating the dual-specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7. NCBI Gene notes that it preferentially activates JNK and acts as a positive regulator of the JNK signalling pathway.
The MAP3K11 protein also contributes to other signalling routes. It plays a role in mitogen-stimulated phosphorylation and activation of BRAF, although it does not phosphorylate BRAF directly. It can directly phosphorylate and activate IkappaB kinase alpha and beta. It is also involved in NF-kappaB transcriptional activity mediated by Rho family GTPases and CDC42. Beyond kinase cascades, it influences microtubule organization during the cell cycle, and UniProt places it at the centrosome within the cytoplasm.
The MAP3K11 gene encodes a protein that contains an SH3 domain and a leucine zipper-basic motif. It belongs to the protein kinase superfamily, the STE Ser/Thr protein kinase family and the MAP kinase kinase kinase subfamily. HGNC classifies it in the mixed lineage kinase family, which explains the alias MLK3, and among SH3 domain containing proteins. Other names in use include SPRK, MEKK11 and PTK1. Orthologues are annotated in mouse and rat as Map3k11, which supports comparative work in rodent models.
MAP3K11 activates MAP2K4 and MAP2K7 and positively regulates JNK signalling, making it a useful node for studying the JUN N-terminal pathway.
The kinase is required for serum-stimulated cell proliferation and for mitogen and cytokine activation of p38, ERK and JNK1.
MAP3K11 phosphorylates IkappaB kinase alpha and beta and contributes to NF-kappaB activity driven by Rho family GTPases and CDC42.
MAP3K11 localises to the centrosome and influences microtubule organization during the cell cycle.
MAP3K11 is a serine/threonine kinase that activates the JUN N-terminal pathway. It phosphorylates and activates MAP2K4 and MAP2K7, which in turn drive JNK, p38 and ERK activation in response to mitogens and cytokines. It also influences microtubule organization during the cell cycle.
These are alternative names and previous symbols for the same gene. MLK3 reflects its place in the mixed lineage kinase family, while MEKK11 reflects its MAP kinase kinase kinase function. HGNC lists MAP3K11 as the approved symbol, so searching all names helps cover the literature.
Yes. Mouse and rat both carry a Map3k11 orthologue of the human gene. This allows the kinase to be studied in rodent systems. For any specific reagent, check the datasheet of any product for its validated reactivity.
Other MAP kinase kinase kinases, the MAP2K kinases that MAP3K11 activates and related signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16584; product specifications from Assay Genie datasheets.