ATG13
ATG13 (autophagy related 13, also known as KIAA0652) is an autophagy factor required for autophagosome formation and mitophagy. It is a target of the TOR kinase signalling pathway and works with ULK1 to control autophagy. Browse Assay Genie's current range of ATG13 research reagents below, or read on for the biology behind the target.
ATG13 is an autophagy factor that is required for autophagosome formation and for mitophagy, the selective autophagic removal of mitochondria. It is a target of the TOR kinase signalling pathway, which regulates autophagy by controlling the phosphorylation status of ATG13 and ULK1. This pathway also governs the ATG13-ULK1-RB1CC1 complex, so the ATG13 protein sits at a point where nutrient and growth signalling is converted into an autophagic response.
Through its regulation of ULK1 activity, ATG13 also plays a role in regulating the kinase activity of mTORC1 and in cell proliferation. This links the autophagy machinery to the control of cell growth. In cells, ATG13 is found in the cytosol and at the preautophagosomal structure, the site where autophagosome formation is organised.
The ATG13 gene belongs to the HGNC gene group "Autophagy related", and the protein belongs to the ATG13 family, metazoan subfamily. The gene was previously designated KIAA0652, and earlier HGNC nomenclature named it as the ATG13 autophagy related 13 homolog (S. cerevisiae). A mouse ortholog, Atg13, is recognised. Researchers studying autophagy initiation, mTORC1 signalling and mitochondrial quality control often investigate ATG13 alongside ULK1 and the other core ATG proteins.
ATG13 is required for autophagosome formation, making it a core protein for studying how autophagy is initiated.
ATG13 is required for mitophagy, so it is relevant to studies of how cells clear mitochondria.
ATG13 is a target of TOR signalling, and its phosphorylation status with ULK1 helps regulate autophagy.
ATG13 forms the ATG13-ULK1-RB1CC1 complex and, through ULK1, influences mTORC1 kinase activity and cell proliferation.
ATG13 is an autophagy factor required for autophagosome formation and mitophagy. It is a target of TOR kinase signalling, which controls the phosphorylation of ATG13 and ULK1 and regulates the ATG13-ULK1-RB1CC1 complex. Via ULK1, it also affects mTORC1 kinase activity and cell proliferation.
The gene was previously known as KIAA0652, and an earlier HGNC name was ATG13 autophagy related 13 homolog (S. cerevisiae). UniProt lists the protein as autophagy-related protein 13. HGNC places it in the gene group "Autophagy related".
ATG13 belongs to the ATG13 family, metazoan subfamily, and the mouse has an ortholog named Atg13. The earlier HGNC name refers to a homolog in S. cerevisiae. Check the datasheet of any product for its validated reactivity.
Other autophagy-related proteins that act alongside ATG13 in autophagosome formation and the autophagy pathway.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75143; product specifications from Assay Genie datasheets.