GDI1
GDI1 (GDP dissociation inhibitor 1) is a member of the Rab GDI family that regulates the GDP/GTP exchange reaction of Rab proteins. It is also known as RABGDIA, XAP-4, OPHN2 and GDIL, and is encoded on the X chromosome. Browse Assay Genie's current range of GDI1 research reagents below, or read on for the biology behind the target.
GDI1 regulates the GDP/GTP exchange reaction of most Rab proteins. It does so by inhibiting the dissociation of GDP from them and the subsequent binding of GTP, which holds the Rab proteins in an inactive state. GDI1 also promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Among the Rab proteins it releases from membranes are RAB1A, RAB3A, RAB5A and RAB10.
Rab proteins are small GTP-binding proteins of the ras superfamily that are involved in vesicular trafficking of molecules between cellular organelles. GDP dissociation inhibitors slow the rate at which GDP leaves Rab proteins and release GDP-bound Rabs from membranes. This makes GDI1 a useful focus for studies of membrane trafficking and the Rab cycle. The GDI1 protein is found in the cytoplasm and in the trans-Golgi network.
The GDI1 gene lies on the X chromosome and encodes the protein also called Rab GDP dissociation inhibitor alpha. Historical and alternative designations include RABGDIA, XAP-4, OPHN2, GDIL, MRX41 and MRX48. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability, which explains the MRX (X-linked intellectual disability) aliases and the interest in this gene in neurobiology.
GDI1 regulates Rab proteins that direct vesicular transport of molecules between cellular organelles, making it central to studies of membrane trafficking.
By inhibiting GDP dissociation and removing GDP-bound Rabs from membranes, GDI1 is used to examine how Rab activation is controlled.
GDI1 is expressed primarily in neural and sensory tissues, so it is relevant to research on neuronal function and development.
Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability, supporting disease-focused genetic and functional research.
GDI1 regulates the GDP/GTP exchange reaction of most Rab proteins. It inhibits the release of GDP from them and the subsequent binding of GTP, and it promotes the removal of GDP-bound Rab proteins from membranes, including RAB1A, RAB3A, RAB5A and RAB10.
The protein is called Rab GDP dissociation inhibitor alpha in UniProt. Aliases and earlier symbols include RABGDIA, XAP-4, OPHN2, FLJ41411, MRX48, MRX41 and GDIL. All refer to the same gene, which belongs to the Rab GDI family.
Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. Orthologues named Gdi1 exist in mouse and rat, so rodent models can be used for study. Check the datasheet of any product for its validated reactivity.
Rab GTPases and other regulators of vesicular trafficking with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31150; product specifications from Assay Genie datasheets.