SOX11
SOX11 (SRY-box transcription factor 11) is a nuclear transcription factor of the SOX family that activates gene transcription and contributes to embryonic development and cell fate determination. It is also known by its previous names SRY (sex determining region Y)-box 11 and SRY-box 11. Browse Assay Genie's current range of SOX11 research reagents below, or read on for the biology behind the target.
SOX11 acts as a transcriptional activator. It binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 at gene promoters, and this partnership enhances transcriptional activation. It also activates TEAD2 by binding to the promoter and first intron of that gene. The NCBI Gene summary notes that the protein may act as a transcriptional regulator after forming a complex with other proteins.
In development, SOX11 plays a role redundant with SOX4 and SOX12 in the survival of cells in developing tissues such as the neural tube, branchial arches and somites, and so contributes to organogenesis. The protein may also function in the developing nervous system.
The SOX11 gene belongs to the SRY-box transcription factors group (SRY-related HMG-box family), whose members regulate embryonic development and the determination of cell fate. The gene is intronless. Its protein is nuclear, and the mouse and rat orthologs are both named Sox11. According to the NCBI Gene summary, the protein may play a role in tumorigenesis, which makes it a point of interest in both developmental and cancer biology. Earlier HGNC names for the gene were SRY (sex determining region Y)-box 11 and SRY-box 11.
SOX11 may function in the developing nervous system and supports cell survival in the neural tube, making it a useful focus for neural development studies.
SOX11 acts redundantly with SOX4 and SOX12 to maintain survival in the branchial arches and somites, contributing to organogenesis.
SOX11 activates transcription, binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6, and drives TEAD2 expression through its promoter and first intron.
The protein may play a role in tumorigenesis, so SOX11 is studied in relation to cell fate control and cancer biology.
SOX11 is a nuclear transcriptional activator. It binds gene promoters, cooperatively with POU3F2/BRN2 or POU3F1/OCT6, and activates TEAD2. It also works redundantly with SOX4 and SOX12 to support cell survival in developing tissues, contributing to organogenesis.
The HGNC name is SRY-box transcription factor 11, and UniProt lists the protein as Transcription factor SOX-11. Previous gene names were SRY (sex determining region Y)-box 11 and SRY-box 11. No alternative gene symbols are recorded. Check the datasheet of any product for its validated reactivity.
Mouse and rat both have a Sox11 ortholog. SOX11 belongs to the SOX family, which regulates embryonic development and cell fate. The NCBI Gene summary states that the protein may function in the developing nervous system and play a role in tumorigenesis.
Other SOX family transcription factors, including SOX4, a redundant partner of SOX11 in developing tissues.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35716; product specifications from Assay Genie datasheets.