WDR33
WDR33 (WD repeat domain 33) is a nuclear WD repeat protein that is essential for both cleavage and polyadenylation of pre-mRNA 3' ends. It is also known as WDC146, NET14 and FLJ11294, and belongs to the cleavage and polyadenylation specific factor subunits. Browse Assay Genie's current range of WDR33 research reagents below, or read on for the biology behind the target.
WDR33 is essential for both cleavage and polyadenylation of pre-mRNA 3' ends, the processing steps that produce mature messenger RNA. HGNC places it among the cleavage and polyadenylation specific factor subunits, and UniProt classifies the protein in the WD repeat WDR33 family. The official protein name is pre-mRNA 3' end processing protein WDR33.
The WDR33 gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids, typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family take part in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. The WDR33 protein is localised to the nucleus, and the gene is highly expressed in testis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
The NCBI Gene summary suggests that the gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. The gene has also been catalogued under the names WDC146, NET14 and FLJ11294, and a mouse ortholog, Wdr33, is recognised. Researchers studying mRNA maturation, 3' end formation and WD repeat complexes use WDR33 as a reference point within the polyadenylation machinery.
WDR33 is essential for both cleavage and polyadenylation of pre-mRNA 3' ends, making it central to studies of mRNA maturation.
As a cleavage and polyadenylation specific factor subunit, WDR33 is relevant to work on how multiprotein processing complexes are assembled.
WD repeats may facilitate multiprotein complexes in processes such as cell cycle progression, signal transduction, apoptosis and gene regulation.
WDR33 is highly expressed in testis and may contribute to cytodifferentiation and/or DNA recombination mechanisms.
WDR33 is essential for both cleavage and polyadenylation of pre-mRNA 3' ends. It is a nuclear protein and is classed among the cleavage and polyadenylation specific factor subunits. Its WD repeats may help it form multiprotein complexes.
WDR33 is also known as WDC146, NET14 and FLJ11294. Its full name is WD repeat domain 33, and UniProt lists it as pre-mRNA 3' end processing protein WDR33. NCBI reports multiple alternatively spliced transcript variants that encode distinct isoforms.
A mouse ortholog, Wdr33, is recognised. In humans the gene is highly expressed in testis and the protein is localised to the nucleus. Check the datasheet of any product for its validated reactivity.
Other WD repeat domain proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9C0J8; product specifications from Assay Genie datasheets.