FOXE3
FOXE3 (forkhead box E3, also known as FREAC8 or FKHL12) is a nuclear transcription factor of the forkhead family that acts in the developing lens. It regulates lens epithelial cell growth and is important for formation of the anterior segment of the eye. Browse Assay Genie's current range of FOXE3 research reagents below, or read on for the biology behind the target.
FOXE3 is a transcription factor that controls lens epithelial cell growth by regulating proliferation, apoptosis and the cell cycle. During lens development it sets the ratio of lens fibre cells to the cells of the anterior lens epithelium, acting on the rate of proliferation and differentiation. It also controls lens vesicle closure and the subsequent separation of the lens vesicle from the ectoderm.
FOXE3 controls the expression of DNAJB1 in a pathway that is crucial for development of the anterior segment of the eye. The protein localises to the nucleus, consistent with its role in gene regulation. The human FOXE3 gene is intronless and belongs to the forkhead family of transcription factors, which is characterised by a distinct forkhead domain. HGNC places it in the forkhead boxes gene group. Mouse and rat orthologs are both named Foxe3.
The encoded protein functions as a lens-specific transcription factor and has an important role in vertebrate lens formation. Mutations in the gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia, which makes FOXE3 a frequent subject in studies of eye development and inherited ocular disease. Earlier names for the gene include FREAC8 and FKHL12.
FOXE3 is a lens-specific transcription factor with an important role in vertebrate lens formation and lens vesicle closure.
FOXE3 regulates proliferation, apoptosis and the cell cycle in lens epithelial cells, making it a model for studying growth control.
Mutations in FOXE3 are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia.
FOXE3 controls DNAJB1 expression in a pathway needed for anterior eye segment development, illustrating forkhead factor target gene regulation.
FOXE3 is a transcription factor that controls lens epithelial cell growth through proliferation, apoptosis and cell cycle regulation. It balances lens fibre cells against anterior epithelial cells, controls lens vesicle closure and separation from the ectoderm, and regulates DNAJB1 expression during anterior eye segment development.
FOXE3 stands for forkhead box E3, and the protein is listed as forkhead box protein E3. Aliases and earlier symbols include FREAC8 and FKHL12. It belongs to the forkhead boxes gene group, and its gene is intronless, so a single protein-coding sequence is described in the gene summary.
Mutations in the FOXE3 gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. Orthologs exist in mouse and rat, both named Foxe3. Check the datasheet of any product for its validated reactivity.
Other forkhead transcription factors and eye development targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13461; product specifications from Assay Genie datasheets.