RGN
RGN (regucalcin, also known as SMP30 and RC) is a highly conserved, cytoplasmic calcium-binding protein with gluconolactonase activity. It modulates Ca(2+) signalling and is preferentially expressed in the liver and kidney. Browse Assay Genie's current range of RGN research reagents below, or read on for the biology behind the target.
RGN is a gluconolactonase, with low activity towards other sugar lactones, including gulonolactone and galactonolactone. In vitro, it can also hydrolyse diisopropyl phosphorofluoridate and phenylacetate. It is also a calcium-binding protein that modulates Ca(2+) signalling, as well as Ca(2+)-dependent cellular processes and enzyme activities. UniProt locates it in the cytoplasm.
The RGN gene encodes a highly conserved protein that is preferentially expressed in the liver and kidney, and it may have an important role in calcium homeostasis. The protein belongs to the SMP-30/CGR1 family. The gene lies in a cluster on chromosome Xp11.3-Xp11.23, and alternative splicing results in multiple transcript variants. Mouse and rat both have an ortholog named Rgn.
The protein was previously named regucalcin (senescence marker protein-30), and the alias SMP30 reflects this history. Studies in rat indicate that it may also play a role in aging, as it shows age-associated down-regulation. This makes the RGN protein a point of interest for researchers studying calcium handling, sugar lactone metabolism and ageing-related change in liver and kidney tissue.
RGN modulates Ca(2+) signalling and Ca(2+)-dependent cellular processes and enzyme activities, making it relevant to studies of calcium regulation.
This calcium-binding protein may have an important role in calcium homeostasis, particularly in the tissues where it is preferentially expressed.
Studies in rat show age-associated down-regulation of the protein, which links RGN to investigations of aging and senescence markers.
Preferential expression in the liver and kidney makes RGN a useful subject for work on the biology of these organs.
RGN acts as a gluconolactonase, with low activity towards other sugar lactones such as gulonolactone and galactonolactone. It also binds calcium and modulates Ca(2+) signalling, along with Ca(2+)-dependent cellular processes and enzyme activities. It may have an important role in calcium homeostasis.
RGN stands for regucalcin and is also called SMP30 and RC. The previous name was regucalcin (senescence marker protein-30). The gene produces multiple transcript variants through alternative splicing, and the protein belongs to the SMP-30/CGR1 family.
RGN is described as highly conserved, with mouse and rat orthologs both named Rgn. Studies in rat indicate that the protein shows age-associated down-regulation and may play a role in aging. Check the datasheet of any product for its validated reactivity.
Other calcium-binding proteins, metabolic enzymes and ageing markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q15493; product specifications from Assay Genie datasheets.