SLC9A3
SLC9A3 (solute carrier family 9 member A3, also known as NHE3 or NHE-3) is a plasma membrane Na+/H+ antiporter. It is the major apical sodium/hydrogen exchanger in kidney and intestine, where it supports sodium absorption and pH homeostasis. Browse Assay Genie's current range of SLC9A3 research reagents below, or read on for the biology behind the target.
SLC9A3 is a plasma membrane Na+/H+ antiporter. It exchanges intracellular H+ ions for extracellular Na+ in a 1:1 stoichiometry, using the inward sodium gradient to expel acid from the cell. Through this activity it plays a key role in salt and fluid absorption and in pH homeostasis. UniProt describes it as the major apical Na+/H+ exchanger in kidney and intestine, with an important role in renal and intestinal Na+ absorption and in blood pressure regulation.
The protein, also called sodium/hydrogen exchanger 3 or NHE3, is an epithelial brush border exchanger. UniProt places it at the apical cell membrane and the cell membrane, and also in recycling endosome and early endosome membranes. It belongs to the monovalent cation:proton antiporter 1 (CPA1) family (TC 2.A.36) and to the HGNC solute carrier family 9 gene group. Researchers studying the SLC9A3 gene or the NHE3 protein often do so in the context of epithelial transport.
Defects in the SLC9A3 gene are a cause of congenital secretory sodium diarrhoea, according to the NCBI Gene summary. The same summary notes that pseudogenes of this gene exist on chromosomes 10 and 22. Earlier HGNC names for the gene include solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 and member 3, and solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3. Mouse and rat both carry an ortholog named Slc9a3.
SLC9A3 is a major apical Na+/H+ exchanger in the intestine, contributing to Na+ absorption and fluid uptake across the epithelium.
As the major apical exchanger in kidney, SLC9A3 has an important role in renal Na+ absorption.
UniProt links SLC9A3 activity in kidney and intestine to blood pressure regulation through its control of sodium absorption.
Defects in SLC9A3 cause congenital secretory sodium diarrhoea, making it a focus for studies of epithelial transport disorders.
SLC9A3 is a plasma membrane Na+/H+ antiporter that exchanges intracellular H+ for extracellular Na+ in a 1:1 ratio. This supports salt and fluid absorption and pH homeostasis. It is the major apical Na+/H+ exchanger in kidney and intestine.
Yes. NHE3 and NHE-3 are aliases of SLC9A3, and UniProt names the protein sodium/hydrogen exchanger 3. Earlier HGNC names described it as solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 or member 3. Check the datasheet of any product for its validated reactivity.
The NCBI Gene summary states that defects in SLC9A3 cause congenital secretory sodium diarrhoea. Orthologs named Slc9a3 are recorded in both mouse and rat. Check the datasheet of any product for its validated reactivity.
Other solute carrier transporters involved in epithelial ion and solute transport, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P48764; product specifications from Assay Genie datasheets.