SLC30A5
SLC30A5, also known as ZnT-5, ZNT5, ZTL1 and ZNTL1, is a proton-coupled zinc antiporter of the SLC30A/ZnT family. It mediates influx and efflux of zinc ions and acts in the early secretory pathway. Browse Assay Genie's current range of SLC30A5 research reagents below, or read on for the biology behind the target.
SLC30A5 is a zinc ion:proton antiporter. According to UniProt, it mediates both influx and efflux of zinc at the plasma membrane. Like other ZnT proteins, it contributes to cellular zinc efflux and to zinc sequestration into membrane-bound organelles. It belongs to the cation diffusion facilitator (CDF) transporter family (TC 2.A.4), SLC30A subfamily, and has no assigned EC number.
The SLC30A5 gene encodes a protein that, as a heterodimer with zinc transporter 6, plays a role in the early secretory pathway. It may also regulate zinc sequestration into secretory granules of pancreatic beta cells. UniProt records a broad subcellular distribution: Golgi stack and trans-Golgi network membranes, COPII-coated and secretory vesicle membranes, the endoplasmic reticulum membrane, and the plasma membrane, including its apical and lateral regions. Researchers studying the SLC30A5 protein therefore often consider it alongside secretory trafficking and zinc handling.
The gene is a member of the HGNC solute carrier family 30 group. Its previous name was solute carrier family 30 (zinc transporter), member 5, and it has also appeared in the literature as ZnT-5, ZNT5, ZTL1 and ZNTL1. NCBI Gene reports that alternatively spliced transcript variants encode multiple isoforms, and that a pseudogene lies on the long arm of chromosome 19. The mouse ortholog is Slc30a5.
SLC30A5 mediates zinc influx and efflux and supports sequestration into organelles, making it relevant to studies of cellular zinc balance.
Working with zinc transporter 6 as a heterodimer, SLC30A5 functions in the early secretory pathway.
SLC30A5 may regulate zinc sequestration into secretory granules of pancreatic beta cells.
As an SLC30A/ZnT member of the cation diffusion facilitator family, SLC30A5 is a model for proton-coupled zinc antiport.
SLC30A5 is a zinc ion:proton antiporter that mediates influx and efflux of zinc at the plasma membrane. ZnT proteins also move zinc into membrane-bound organelles. SLC30A5 acts in the early secretory pathway as a heterodimer with zinc transporter 6.
SLC30A5 is also called ZnT-5, ZNT5, ZTL1, ZNTL1, FLJ12496, FLJ12756 and MGC5499. Its former name was solute carrier family 30 (zinc transporter), member 5. NCBI Gene reports alternatively spliced transcript variants that encode multiple isoforms.
A mouse ortholog, Slc30a5, is recorded for this gene. The protein belongs to the cation diffusion facilitator family, SLC30A subfamily. Check the datasheet of any product for its validated reactivity.
Other solute carrier family members, including metal ion and vesicular transporters, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TAD4; product specifications from Assay Genie datasheets.