ARHGAP25
ARHGAP25 (Rho GTPase activating protein 25, also known as KIAA0053) is a GTPase-activating protein that switches Rho-type GTPases into their inactive, GDP-bound state. It belongs to the ARHGAP group of negative regulators of Rho signalling. Browse Assay Genie's current range of ARHGAP25 research reagents below, or read on for the biology behind the target.
ARHGAP25 acts as a GTPase activator for the Rho-type GTPases. It converts them to an inactive GDP-bound state, which makes it a negative regulator of Rho signalling. Rho GTPases cycle between active GTP-bound and inactive GDP-bound forms, and GTPase-activating proteins such as ARHGAP25 drive the transition to the inactive form.
According to the NCBI Gene summary, ARHGAP genes encode negative regulators of Rho GTPases, which are implicated in actin remodelling, cell polarity and cell migration. The ARHGAP25 gene therefore sits within a pathway that controls cytoskeletal organisation and cell behaviour. The ARHGAP25 protein is a member of the HGNC groups for pleckstrin homology domain containing proteins and Rho GTPase activating proteins. The mouse ortholog is Arhgap25. Subcellular location is not annotated in UniProt.
The gene is also listed under the earlier symbol KIAA0053. Researchers studying Rho family regulation often compare ARHGAP25 with other ARHGAP family members to understand how individual GAPs contribute to Rho GTPase control. An ARHGAP25 antibody, ARHGAP25 ELISA kit or recombinant ARHGAP25 protein can be used to investigate its expression and function in these contexts.
ARHGAP25 converts Rho-type GTPases to an inactive GDP-bound state, making it a useful node for studying negative regulation of Rho signalling.
ARHGAP proteins regulate Rho GTPases that are implicated in actin remodelling, so ARHGAP25 is relevant to cytoskeletal dynamics.
Negative regulators of Rho GTPases, including ARHGAP25, are linked to the control of cell polarity.
Rho GTPase regulation by ARHGAP family members is implicated in cell migration, a context in which ARHGAP25 can be studied.
ARHGAP25 is a GTPase activator for Rho-type GTPases. It converts them to an inactive GDP-bound state, acting as a negative regulator. Rho GTPases are implicated in actin remodelling, cell polarity and cell migration, which are the processes this regulation influences.
The gene is named Rho GTPase activating protein 25 by HGNC, and UniProt lists the protein as Rho GTPase-activating protein 25. KIAA0053 is a listed alias. HGNC places it in the pleckstrin homology domain containing and Rho GTPase activating protein groups.
A mouse ortholog, Arhgap25, is recorded for the human gene. A rat ortholog is not given in the data used here. For experimental work, check the datasheet of any product for its validated reactivity.
Other Rho GTPase-activating proteins in the ARHGAP family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P42331; product specifications from Assay Genie datasheets.