LACRT
LACRT (lacritin) is a secreted extracellular glycoprotein that modulates secretion by lacrimal acinar cells. It is highly expressed in the lacrimal glands, where it is found in secretory granules and secretory fluid. Browse Assay Genie's current range of LACRT research reagents below, or read on for the biology behind the target.
LACRT, or lacritin, is an extracellular glycoprotein whose annotated function is to modulate secretion by lacrimal acinar cells. According to the NCBI Gene summary, it augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and stimulates signalling through tyrosine phosphorylation and the release of calcium. These activities place lacritin among the factors that influence the function of the lacrimal gland.
The protein encoded by the LACRT gene is highly expressed in the lacrimal glands. Within the tissue it is localised primarily to secretory granules and to secretory fluid, which is consistent with its UniProt classification as a secreted protein. Researchers studying lacritin therefore tend to focus on glandular secretory material and on the cellular responses it triggers.
The HGNC-approved name is lacritin, and the symbol LACRT is also written in full as LACRITIN. The source data record no further family assignment or enzymatic activity, so the biology of the lacritin protein is best described through its secretory and signalling effects on lacrimal acinar and ductal cells. Reagents for lacritin, such as a LACRT antibody or LACRT ELISA kit, support work on this secretory pathway.
LACRT is highly expressed in the lacrimal glands, making it a relevant protein for studying how these glands function.
Lacritin modulates secretion by lacrimal acinar cells and augments their secretory output, so it is useful for examining secretory regulation.
Lacritin promotes ductal cell proliferation, which makes it a candidate factor for studying growth responses in lacrimal duct cells.
Lacritin stimulates signalling through tyrosine phosphorylation and calcium release, providing a way to probe these intracellular events.
LACRT (lacritin) modulates secretion by lacrimal acinar cells. The NCBI Gene summary adds that it augments acinar cell secretion, promotes ductal cell proliferation, and stimulates signalling through tyrosine phosphorylation and the release of calcium.
The HGNC-approved name is lacritin, and LACRITIN is recorded as an alias. UniProt lists the protein as extracellular glycoprotein lacritin. No previous symbols or isoform details are given in the source data.
Lacritin is highly expressed in the lacrimal glands and localises primarily to secretory granules and secretory fluid. UniProt annotates it as a secreted protein. Check the datasheet of any product for its validated reactivity.
Other secreted proteins and factors involved in glandular secretion and calcium signalling with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9GZZ8; product specifications from Assay Genie datasheets.