ICAM5
ICAM5 (intercellular adhesion molecule 5, also known as TLN and TLCN) is a cell adhesion molecule of the immunoglobulin superfamily. It mediates adhesion between neurons and between neurons and leukocytes, and is expressed on the surface of telencephalic neurons. Browse Assay Genie's current range of ICAM5 research reagents below, or read on for the biology behind the target.
ICAM5 functions as a cell adhesion molecule and as a receptor ligand of the signalling receptor ITGAL:ITGB2, also called LFA-1 (lymphocyte-function associated molecule 1), ensuring adhesion between neurons and leukocytes. It also forms homophilic contacts, in which ICAM5 on one cell binds ICAM5 on another, and this homophilic adhesion promotes dendritogenesis and arborisation of hippocampal neurons. The protein therefore displays two types of adhesion activity: homophilic binding between neurons and heterophilic binding between neurons and leukocytes.
The ICAM5 gene encodes a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind the leukocyte adhesion protein LFA-1. HGNC places the gene in the immunoglobulin-like domain containing group and the Ig-like cell adhesion molecule family. Unlike other family members, ICAM5 is expressed on the surface of telencephalic neurons, which is reflected in its alias telencephalin (TLN). UniProt records it at the cell membrane, including cell projections, the uropodium and the dendritic spine membrane. Mouse and rat both have an Icam5 ortholog.
Because it links neurons to leukocytes, ICAM5 may be a critical component of neuron-microglial cell interactions, either during normal development or as part of neurodegenerative diseases. This makes the ICAM5 protein a useful subject for studies of neuronal morphology and neuroimmune communication, alongside the better-known family members ICAM-1, ICAM2, ICAM3 and ICAM4.
ICAM5 homophilic adhesion promotes dendritogenesis and arborisation of hippocampal neurons, making it relevant to studies of dendrite formation.
ICAM5 may be a critical component of neuron-microglial cell interactions during normal development and in neurodegenerative disease.
As a ligand of LFA-1 (ITGAL:ITGB2), ICAM5 mediates neuron-leukocyte adhesion, a route for investigating immune cell contact with neurons.
ICAM5 shows both homophilic and heterophilic adhesion, offering a model for comparing ICAM family members and immunoglobulin-like adhesion mechanisms.
ICAM5 is a cell adhesion molecule. It acts as a ligand for the LFA-1 receptor (ITGAL:ITGB2), supporting neuron-leukocyte adhesion, and it forms homophilic contacts between neurons that promote dendritogenesis and arborisation of hippocampal neurons.
ICAM5 stands for intercellular adhesion molecule 5. The gene is also known by the aliases TLN and TLCN, reflecting the name telencephalin, which refers to its expression on the surface of telencephalic neurons. HGNC lists no previous gene names.
Yes. Mouse and rat each have an ortholog named Icam5. The human protein belongs to the immunoglobulin superfamily and the ICAM family; check the datasheet of any product for its validated reactivity.
Other ICAM family adhesion molecules that share LFA-1 binding and immunoglobulin-like domains with ICAM5.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UMF0; product specifications from Assay Genie datasheets.