DLX3
DLX3 (distal-less homeobox 3) is a homeobox-containing transcription factor of the distal-less homeobox family. It acts as a transcriptional activator, and mutations in the DLX3 gene are linked to trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. Browse Assay Genie's current range of DLX3 research reagents below, or read on for the biology behind the target.
DLX3 is a transcriptional activator. One characterised target is GNRHR: DLX3 activates transcription of this gene by binding the downstream activin regulatory element (DARE) in its promoter. The protein, annotated in UniProt as Homeobox protein DLX-3, is found in the nucleus and the cytoplasm, consistent with its role as a DNA-binding regulator of gene expression.
DLX3 belongs to the distal-less homeobox family. Many vertebrate homeobox-containing genes were identified through sequence similarity with Drosophila developmental genes, and members of the Dlx family carry a homeobox related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The family comprises at least six members, DLX1 to DLX6. The DLX3 gene lies in a tail-to-tail configuration with another family member on the long arm of chromosome 17, and the mouse ortholog is Dlx3. Related family members include DLX4 and DLX5.
DLX3 is of clinical interest because mutations in the gene are associated with two autosomal dominant conditions: trichodentoosseous syndrome (TDO) and amelogenesis imperfecta with taurodontism. HGNC records the previous name as distal-less homeo box 3. Researchers studying DLX3 often use the DLX3 antibody, DLX3 ELISA kit or DLX3 protein reagents to examine expression and function.
DLX3 activates GNRHR transcription through the downstream activin regulatory element, making it a model for studying homeodomain control of promoter activity.
Dlx genes are related to Drosophila Distal-less, expressed in the developing head and limbs, so DLX3 is relevant to studies of homeobox-driven development.
DLX3 mutations are associated with trichodentoosseous syndrome, an autosomal dominant condition, and with amelogenesis imperfecta with taurodontism.
DLX3 is one of at least six DLX genes, allowing comparison of family members such as DLX4 and DLX5.
DLX3 is a transcriptional activator. UniProt reports that it activates transcription of GNRHR by binding the downstream activin regulatory element (DARE) in the gene promoter. The protein localises to the nucleus and the cytoplasm. Check the datasheet of any product for its validated reactivity.
The HGNC symbol is DLX3 and the full name is distal-less homeobox 3, previously written distal-less homeo box 3. UniProt names the protein Homeobox protein DLX-3. No other aliases or previous symbols are listed in the source data.
Mutations in the DLX3 gene are associated with trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism, both autosomal dominant conditions. The gene belongs to the distal-less family, related to Drosophila Distal-less, and has a mouse ortholog, Dlx3.
Other members of the distal-less homeobox family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60479; product specifications from Assay Genie datasheets.