COIL
COIL, also known as coilin, p80-coilin or CLN80, is an integral component of Cajal bodies (coiled bodies), nuclear suborganelles involved in the modification and assembly of small nuclear ribonucleoproteins. It is the defining marker protein of these structures. Browse Assay Genie's current range of COIL research reagents below, or read on for the biology behind the target.
COIL (coilin) is a component of nuclear coiled bodies, also known as Cajal bodies, which are involved in the modification and assembly of nucleoplasmic snRNPs. Cajal bodies are nuclear suborganelles of varying number and composition, and they take part in the post-transcriptional modification of small nuclear and small nucleolar RNAs. Coilin is an integral component of these bodies and is found in the nucleus, concentrated in the Cajal body.
The protein belongs to the coilin family. Its domains appear to have distinct roles: the N-terminus directs self-oligomerisation of the protein, while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin are thought to influence its localisation among nuclear bodies, as well as the composition and assembly of Cajal bodies. These post-translational modifications make coilin a useful focus for work on how nuclear body architecture is regulated.
The human COIL gene has pseudogenes on chromosome 4 and chromosome 14, which is worth bearing in mind when designing nucleic acid-based assays. The protein is also known as p80-coilin, reflecting its apparent molecular size on gels, and by the alias CLN80. A mouse ortholog, Coil, has been identified.
Coilin is an integral component of Cajal bodies, making it a central protein for studying the structure and composition of these nuclear suborganelles.
Cajal bodies are involved in the modification and assembly of nucleoplasmic snRNPs, so coilin is relevant to work on snRNP maturation.
Cajal bodies contribute to post-transcriptional modification of small nuclear and small nucleolar RNAs, placing coilin within non-coding RNA processing pathways.
Methylation and phosphorylation of coilin likely influence its localisation among nuclear bodies and Cajal body assembly, offering a model for nuclear body regulation.
COIL encodes coilin, an integral component of Cajal bodies. These nuclear suborganelles are involved in the modification and assembly of nucleoplasmic snRNPs and in the post-transcriptional modification of small nuclear and small nucleolar RNAs. Coilin's N-terminus drives self-oligomerisation, and its C-terminus influences how many nuclear bodies form per cell.
COIL is the HGNC symbol for the gene encoding coilin. The protein is also called p80-coilin, and CLN80 is a recorded alias. Cajal bodies, the structures it belongs to, are also called coiled bodies, which is the origin of the gene and protein names.
A mouse ortholog, Coil, is recorded for the human gene. The human gene also has pseudogenes on chromosome 4 and chromosome 14. The protein belongs to the coilin family. Check the datasheet of any product for its validated reactivity.
Other nuclear body components, snRNP assembly factors and RNA-processing proteins studied alongside coilin.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P38432; product specifications from Assay Genie datasheets.