SEPTIN7
SEPTIN7 (septin 7, also known as CDC10, CDC3 or SEPT7) is a filament-forming cytoskeletal GTPase of the septin family. It supports actin organisation, mitosis and cytokinesis, and contributes to ciliogenesis and sperm tail structure. Browse Assay Genie's current range of SEPTIN7 research reagents below, or read on for the biology behind the target.
SEPTIN7 is a filament-forming cytoskeletal GTPase. It is required for normal organisation of the actin cytoskeleton and for normal progress through mitosis, and it is involved in cytokinesis. It is also needed for the normal association of CENPE with the kinetochore, and it plays a role in ciliogenesis and collective cell movements. In the sperm annulus it forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4, which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.
The SEPTIN7 protein belongs to the septin GTPase family, part of the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, and carries a GTP-binding motif. UniProt records its localisation to the cytoplasm, the kinetochore at the centromere, the spindle, the cleavage furrow and the midbody, as well as the cilium axoneme and flagellum. The human SEPTIN7 gene has mouse and rat orthologs, both named Septin7. Alternative splicing of the gene produces multiple transcript variants, and several related pseudogenes are found on other chromosomes.
The gene was named for its strong similarity to yeast CDC10, which is a structural component of the 10 nm filament lying inside the cytoplasmic membrane and is essential for cytokinesis. The protein also resembles Diff 6 of Drosophila and H5 of mouse. HGNC lists the previous name as CDC10 cell division cycle 10 homolog (S. cerevisiae). In humans, SEPTIN7 functions in gliomagenesis and in suppressing glioma cell growth.
SEPTIN7 is involved in cytokinesis and is required for normal progress through mitosis, making it a useful target for studying cell division.
SEPTIN7 is required for the normal association of CENPE with the kinetochore, linking septin function to chromosome segregation.
SEPTIN7 plays a role in ciliogenesis and forms part of the sperm annulus structure needed for sperm tail integrity and motility.
Human SEPTIN7 functions in gliomagenesis and in suppression of glioma cell growth, so it is studied in glioma biology.
SEPTIN7 is a filament-forming cytoskeletal GTPase. It is required for normal actin cytoskeleton organisation, progress through mitosis and cytokinesis, and for CENPE association with the kinetochore. It also plays a role in ciliogenesis, collective cell movements and sperm tail integrity and motility.
SEPTIN7 is also called CDC10, CDC3, SEPT7 and SEPT7A, and UniProt names the protein Septin-7. The previous HGNC name was CDC10 cell division cycle 10 homolog (S. cerevisiae), reflecting its similarity to the yeast protein. Alternative splicing gives multiple transcript variants.
Yes. Mouse and rat both have a Septin7 ortholog. The human protein is highly similar to yeast CDC10, and also resembles Drosophila Diff 6 and mouse H5, all of which contain a GTP-binding motif. Check the datasheet of any product for its validated reactivity.
Other septin family members, including SEPTIN7 filament partners in the sperm annulus, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16181; product specifications from Assay Genie datasheets.