CHD3
CHD3 (chromodomain helicase DNA binding protein 3, also known as Mi-2a, ZFH and Mi2-ALPHA) is an ATP-dependent chromatin remodeller that binds and distorts nucleosomal DNA. It acts as a component of the histone deacetylase NuRD complex and contributes to transcriptional repression. Browse Assay Genie's current range of CHD3 research reagents below, or read on for the biology behind the target.
CHD3 is an ATP-dependent chromatin-remodelling factor that binds and distorts nucleosomal DNA. It is a component of the histone deacetylase NuRD complex, also called the Mi-2/NuRD complex, which participates in chromatin remodelling by deacetylating histones. Through the NuRD complex, CHD3 is involved in transcriptional repression. Chromatin remodelling is essential for many processes, including transcription, which makes the CHD3 protein a useful subject for studies of gene regulation.
CHD3 has a role outside chromatin as well. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, and for spindle organisation and centrosome integrity. Consistent with these roles, UniProt lists its subcellular locations as the nucleus, including PML bodies, and the centrosome within the cytoskeleton. The CHD3 gene encodes a member of the CHD family, whose members are characterised by chromo (chromatin organisation modifier) domains and SNF2-related helicase/ATPase domains. The protein belongs to the SNF2/RAD54 helicase family. HGNC places it among the PHD finger proteins, the SNF2 related family and the NuRD complex subunits.
Autoantibodies against CHD3 are found in a subset of patients with dermatomyositis, which links the protein to autoimmune disease research. Three alternatively spliced transcripts encoding different isoforms have been described. The HGNC gene group also includes small nucleolar RNA protein coding host genes. Related family members such as CHD1L, CHD2, CHD4 and CHD5 are useful comparators when studying chromodomain helicase function.
CHD3 binds and distorts nucleosomal DNA, making it a core subject for work on how ATP-dependent remodellers alter chromatin.
As a component of the Mi-2/NuRD histone deacetylase complex, CHD3 is relevant to histone deacetylation and complex composition.
CHD3 is involved in transcriptional repression as part of the NuRD complex, supporting research into gene silencing mechanisms.
CHD3 is required for anchoring pericentrin, spindle organisation and centrosome integrity in interphase and mitosis.
CHD3 is an ATP-dependent chromatin-remodelling factor that binds and distorts nucleosomal DNA. As part of the NuRD complex it takes part in chromatin remodelling and transcriptional repression. It is also required for anchoring centrosomal pericentrin, spindle organisation and centrosome integrity.
CHD3 is also known as Mi-2a, Mi2-ALPHA and ZFH. Its full name is chromodomain helicase DNA binding protein 3, and UniProt names it ATP-dependent chromatin remodeler CHD3. NCBI Gene describes three alternatively spliced transcripts encoding different isoforms.
NCBI Gene reports that autoantibodies against CHD3 are found in a subset of patients with dermatomyositis. CHD3 belongs to the CHD family and the SNF2/RAD54 helicase family. Check the datasheet of any product for its validated reactivity.
Other CHD family chromatin remodellers and NuRD-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q12873; product specifications from Assay Genie datasheets.