| UniProt Protein Function: | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. |
| NCBI Summary: | This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12873 |
| NCBI GenInfo Identifier: | 88911273 |
| NCBI Gene ID: | 1107 |
| NCBI Accession: | Q12873.3 |
| UniProt Secondary Accession: | Q12873,Q9Y4I0, D3DTQ9, E9PG89, |
| UniProt Related Accession: | Q12873 |
| Molecular Weight: | 233,037 Da |
| NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 3 |
| NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 3 |
| NCBI Official Symbol: | CHD3Â Â |
| NCBI Official Synonym Symbols: | ZFH; Mi-2a; Mi2-ALPHAÂ Â |
| NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 3 |
| UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 3 |
| UniProt Synonym Protein Names: | ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH |
| Protein Family: | CHD3-type chromatin-remodeling factor |
| UniProt Gene Name: | CHD3Â Â |
| UniProt Entry Name: | CHD3_HUMAN |
