SP100
SP100 (SP100 nuclear body protein, also known as nuclear autoantigen Sp-100) is a major constituent of PML nuclear bodies, subnuclear structures involved in cell growth, differentiation and apoptosis. It acts in transcriptional regulation and in host responses to viral infection. Browse Assay Genie's current range of SP100 research reagents below, or read on for the biology behind the target.
SP100 is, together with PML, a major constituent of PML bodies, the subnuclear organelles also called PML-SP100 nuclear bodies. These structures are involved in a large number of physiological processes, including cell growth, differentiation and apoptosis, and SP100 is described as a tumour suppressor. It functions as a transcriptional coactivator of ETS1 and ETS2, and under certain conditions may act as a corepressor of ETS1, preventing its binding to DNA. Through ETS1 regulation, SP100 may influence angiogenesis by controlling endothelial cell motility and invasion.
SP100 may also regulate TP53-mediated transcription and, through CASP8AP2, FAS-mediated apoptosis. Through interaction with the MRN complex it may contribute to the regulation of telomere lengthening. The protein also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. According to the NCBI Gene summary, the encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity and gene regulation.
Both PML and SP100 are covalently modified by SUMO-1, a modification considered crucial to nuclear body interactions. The SP100 gene produces alternatively spliced variants, one of which encodes a high-mobility group protein. HGNC places SP100 in the PHD finger, bromodomain-containing and SAND domain-containing protein groups. UniProt records localisation to the nucleus, including PML bodies and other nuclear bodies, and to the cytoplasm. Earlier names for the gene include SP100 nuclear antigen and nuclear antigen Sp100. The mouse ortholog is Sp100.
SP100 is a major PML body component, making it a core marker for studying these organelles and their roles in growth, differentiation and apoptosis.
SP100 coactivates or corepresses ETS1 and ETS2 and may regulate TP53-mediated transcription, making it relevant to gene regulation studies.
SP100 contributes to infection by human cytomegalovirus and Epstein-Barr virus, possibly through chromatin or transcriptional regulation.
Described as a tumour suppressor, SP100 may control endothelial cell motility and invasion through ETS1, linking it to cancer and angiogenesis research.
SP100 is a major component of PML nuclear bodies, with roles in cell growth, differentiation and apoptosis. It coactivates ETS1 and ETS2, may corepress ETS1 under certain conditions, may regulate TP53-mediated transcription, and may influence telomere lengthening through the MRN complex.
UniProt lists it as nuclear autoantigen Sp-100, and earlier HGNC names include SP100 nuclear antigen and nuclear antigen Sp100. The gene has alternatively spliced variants, one of which encodes a high-mobility group protein. Check the datasheet of any product for its validated reactivity.
SP100 is described as a tumour suppressor and is thought to play a role in tumorigenesis and immunity. It also plays a role in infection by human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and transcriptional regulation. A mouse ortholog, Sp100, exists.
Other SP-prefixed transcription factors and nuclear proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P23497; product specifications from Assay Genie datasheets.