SLITRK1
SLITRK1 (SLIT and NTRK like family member 1, also known as KIAA1910 or LRRC12) is an integral membrane protein of the SLITRK family. It is involved in synaptogenesis, promotes excitatory synapse differentiation and enhances neuronal dendrite outgrowth. Browse Assay Genie's current range of SLITRK1 research reagents below, or read on for the biology behind the target.
SLITRK1 is a neuronal protein involved in synaptogenesis. It promotes the differentiation of excitatory synapses and enhances dendrite outgrowth in neurons, and is generally thought to contribute to neurite outgrowth. These activities make the SLITRK1 protein a useful subject for studies of how neuronal connections are built and shaped.
The SLITRK1 gene encodes a member of the SLITRK protein family, whose members are integral membrane proteins. Family members are characterised by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. SLITRK1 differs in this respect, because it lacks the region of homology to neurotrophin receptors. UniProt lists its subcellular locations as membrane, secreted and synapse. Alternative splicing of the gene results in multiple transcript variants. The mouse ortholog is Slitrk1.
The protein has appeared in the literature under several names. Previous HGNC names include leucine rich repeat containing 12 (LRRC12) and SLIT and NTRK-like family, member 1, and KIAA1910 is a further alias. The name reflects the combination of SLIT-like leucine-rich repeats and a trk-like C-terminal region found across the family. Mutations in the gene may be associated with Tourette syndrome, which has drawn attention to SLITRK1 in neuropsychiatric research.
SLITRK1 is involved in synaptogenesis, making it relevant to studies of how synapses are established between neurons.
SLITRK1 promotes excitatory synapse differentiation, so it is studied in work on how excitatory connections mature.
SLITRK1 enhances neuronal dendrite outgrowth and is thought to be involved in neurite outgrowth more broadly.
Mutations in the SLITRK1 gene may be associated with Tourette syndrome, linking the protein to neuropsychiatric disease studies.
SLITRK1 is involved in synaptogenesis and promotes excitatory synapse differentiation. It also enhances neuronal dendrite outgrowth and is thought to contribute to neurite outgrowth. It is an integral membrane protein of the SLITRK family, with UniProt locations including membrane, secreted and synapse.
SLITRK1 is also known as KIAA1910 and LRRC12. Previous names include leucine rich repeat containing 12 and SLIT and NTRK-like family, member 1. Alternative splicing of the gene produces multiple transcript variants, so check the datasheet of any product for its validated reactivity.
Mutations in the SLITRK1 gene may be associated with Tourette syndrome. A mouse ortholog, Slitrk1, is recognised. Unlike some other SLITRK members, human SLITRK1 lacks the region of homology to trk neurotrophin receptors.
Other SLITRK family members and related neuronal synapse targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96PX8; product specifications from Assay Genie datasheets.