AZGP1
AZGP1, also known as zinc-alpha-2-glycoprotein (ZAG, ZA2G), is a secreted protein that stimulates lipid degradation in adipocytes. It belongs to the MHC class I family and is linked to the fat loss seen in some advanced cancers. Browse Assay Genie's current range of AZGP1 research reagents below, or read on for the biology behind the target.
AZGP1 stimulates lipid degradation in adipocytes and is responsible for the extensive fat losses associated with some advanced cancers. UniProt also notes that it may bind polyunsaturated fatty acids. The protein is secreted, which fits a role in signalling to fat tissue and makes it a candidate analyte in body fluids and in studies of lipid metabolism.
The AZGP1 gene encodes zinc-alpha-2-glycoprotein, which belongs to the MHC class I family; HGNC places it in the C1-set domain containing group. The approved gene name is alpha-2-glycoprotein 1, zinc-binding, and the previous name was alpha-2-glycoprotein 1, zinc. Other aliases are ZAG and ZA2G. Mouse and rat both have an orthologous gene, Azgp1, which allows the biology to be studied in rodent models.
NCBI Gene summarises AZGP1 as involved in cell adhesion and in the detection of chemical stimuli involved in the sensory perception of bitter taste. It is predicted to enable RNA nuclease activity and transmembrane protein transporter activity. The gene is implicated in prostate carcinoma and is described as a biomarker of several diseases, including gastrointestinal system cancers, kidney failure, liver cirrhosis, lung adenocarcinoma and obesity. Researchers studying the AZGP1 gene or the zinc-alpha-2-glycoprotein it encodes therefore work across cancer biology, metabolism and biomarker discovery.
AZGP1 stimulates lipid degradation in adipocytes and is linked to the extensive fat losses seen in some advanced cancers.
AZGP1 is described as a biomarker of obesity and acts on adipocyte lipid breakdown, making it relevant to fat metabolism.
AZGP1 is implicated in prostate carcinoma and is a biomarker in gastrointestinal cancers and lung adenocarcinoma.
AZGP1 is reported as a biomarker of liver cirrhosis and kidney failure, supporting its study in organ disease.
AZGP1 is a secreted protein that stimulates lipid degradation in adipocytes and contributes to the extensive fat losses associated with some advanced cancers. UniProt also states that it may bind polyunsaturated fatty acids. NCBI Gene additionally links it to cell adhesion and bitter taste perception.
AZGP1 is the HGNC symbol for alpha-2-glycoprotein 1, zinc-binding. The protein is called zinc-alpha-2-glycoprotein, and the aliases ZAG and ZA2G are also used. The earlier gene name was alpha-2-glycoprotein 1, zinc. Searching under any of these terms should find the same target.
Mouse and rat both carry an Azgp1 ortholog. AZGP1 is implicated in prostate carcinoma and is a biomarker of several conditions, including gastrointestinal cancers, kidney failure, liver cirrhosis, lung adenocarcinoma and obesity. Check the datasheet of any product for its validated reactivity.
Other lipid metabolism, adipokine and MHC class I-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P25311; product specifications from Assay Genie datasheets.