CMTM2 is a membrane protein that belongs to the chemokine-like factor family. According to the NCBI Gene summary, the CMTM2 gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signalling molecules. The encoded protein may play an important role in testicular development, although a detailed biochemical mechanism is not described in the source annotation.

The CMTM2 protein is annotated in UniProt as a membrane protein, and the name reflects its MARVEL transmembrane domain. HGNC places the gene in the group of CKLF like MARVEL transmembrane domain containing genes, which also includes the related CMTM family members CMTM1, CMTM4, CMTM5, CMTM6, CMTM7 and CMTM8. Researchers studying CMTM2 often consider it alongside these relatives to understand how the family is organised.

The gene has been known under several names. Earlier nomenclature includes chemokine-like factor super family 2 (symbol CKLFSF2), and aliases such as MGC39436 and FLJ25732 appear in older literature and database records. These names are useful when searching publications that predate the current CMTM naming. For experimental work, an CMTM2 antibody or CMTM2 ELISA kit is typically used to examine expression of this protein.