ANGPT4
ANGPT4 (angiopoietin 4) is a secreted angiopoietin that binds the endothelial receptor TEK/TIE2 and promotes endothelial cell survival, migration and angiogenesis. It belongs to the angiopoietin family of vascular regulators. Browse Assay Genie's current range of ANGPT4 research reagents below, or read on for the biology behind the target.
ANGPT4 is a secreted ligand that binds to the receptor tyrosine kinase TEK, also known as TIE2. Binding can induce tyrosine phosphorylation of TEK/TIE2 and modulates ANGPT1 signalling. Functionally, ANGPT4 promotes endothelial cell survival, migration and angiogenesis. The NCBI Gene summary describes the protein encoded by this gene as an agonist, so it activates the receptor rather than blocking it.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. Their contribution to angiogenesis is thought to involve regulation of interactions between endothelial cells and supporting perivascular cells. The ANGPT4 gene encodes Angiopoietin-4, and the mouse ortholog is designated Angpt4.
HGNC classifies angiopoietin 4 within the groups receptor ligands, fibrinogen C domain containing proteins and angiopoietins. This places it alongside the angiopoietin-like proteins in sequence-domain terms, although those proteins are distinct gene products. Researchers studying the TEK/TIE2 axis use ANGPT4 to examine how individual angiopoietins differ in modulating ANGPT1 signalling and endothelial behaviour. Reagents such as an ANGPT4 antibody, ANGPT4 ELISA kit or recombinant ANGPT4 protein support this work.
ANGPT4 promotes endothelial cell survival, migration and angiogenesis, making it relevant to studies of new vessel formation.
ANGPT4 binds TEK/TIE2 and can induce its tyrosine phosphorylation, so it is used to probe receptor activation.
Angiopoietins have important roles in vascular development, and ANGPT4 contributes to this family of regulators.
Angiopoietins are thought to regulate endothelial interactions with perivascular cells, a focus for studies of vessel structure.
ANGPT4 is a secreted ligand that binds TEK/TIE2 on endothelial cells and can induce its tyrosine phosphorylation. It modulates ANGPT1 signalling and promotes endothelial cell survival, migration and angiogenesis. The NCBI Gene summary describes it as an agonist.
The HGNC-approved name is angiopoietin 4, and UniProt lists the protein as Angiopoietin-4. No alternative symbols or previous names are recorded. The receptor it binds, TEK, is also known as TIE2, which often appears in the literature alongside ANGPT4.
A mouse ortholog, Angpt4, is recorded for the human ANGPT4 gene. Angiopoietins as a family are described as having important roles in vascular development and angiogenesis; check the datasheet of any product for its validated reactivity.
Angiopoietin-like proteins and other fibrinogen C domain family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y264; product specifications from Assay Genie datasheets.