NKX3-1
NKX3-1 (NK3 homeobox 1, also known as NKX3.1, BAPX2 and NKX3A) is a homeobox-containing transcription factor that restrains epithelial cell growth in prostate tissue. It plays a central role in normal prostate development and acts as a tumour suppressor. Browse Assay Genie's current range of NKX3-1 research reagents below, or read on for the biology behind the target.
NKX3-1 is a transcription factor that binds preferentially to the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. It functions as a negative regulator of epithelial cell growth in prostate tissue. It is important in normal prostate development, where it regulates proliferation of the glandular epithelium and contributes to the formation of ducts in the prostate.
The NKX3-1 gene encodes Homeobox protein Nkx-3.1, a nuclear protein that belongs to the NK-3 homeobox family. HGNC places it in the NKL subclass of homeoboxes and pseudogenes. Alternate splicing of the gene results in multiple transcript variants. The mouse ortholog is designated Nkx3-1, which allows the gene to be studied in murine models of prostate biology.
NKX3-1 is best known as a tumour suppressor controlling prostate carcinogenesis. The protein inhibits both proliferation and invasion in PC-3 prostate cancer cells, and aberrant expression of the gene is associated with prostate tumour progression. The gene has also been catalogued under the names NK homeobox (Drosophila), family 3, A and NK3 transcription factor related, locus 1 (Drosophila), reflecting its relationship to the Drosophila NK homeobox genes. Researchers studying NKX3-1 typically work on homeobox-mediated transcriptional repression, prostate epithelial differentiation and the molecular changes that accompany prostate cancer progression.
NKX3-1 acts as a tumour suppressor in prostate carcinogenesis, and its aberrant expression is associated with prostate tumour progression.
NKX3-1 regulates proliferation of the glandular epithelium and contributes to duct formation during normal prostate development.
The protein binds the consensus sequence 5'-TAAGT[AG]-3' and can act as a transcriptional repressor.
NKX3-1 inhibits proliferation and invasion in PC-3 prostate cancer cells, making it a useful subject for studies of epithelial growth control.
NKX3-1 is a nuclear transcription factor that binds the consensus sequence 5'-TAAGT[AG]-3' and can repress transcription. It negatively regulates epithelial cell growth in the prostate, supports normal prostate development and duct formation, and acts as a tumour suppressor in prostate carcinogenesis.
NKX3-1 is also called NKX3.1, BAPX2 and NKX3A. Its UniProt name is Homeobox protein Nkx-3.1. Earlier HGNC names were NK homeobox (Drosophila), family 3, A and NK3 transcription factor related, locus 1 (Drosophila). Alternate splicing produces multiple transcript variants.
Aberrant NKX3-1 expression is associated with prostate tumour progression, and the protein inhibits proliferation and invasion in PC-3 prostate cancer cells. A mouse ortholog, Nkx3-1, exists; check the datasheet of any product for its validated reactivity.
Other NK-class homeobox transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99801; product specifications from Assay Genie datasheets.