FOXC2
FOXC2 (forkhead box C2, also known as MFH-1 or FKHL14) is a member of the forkhead family of transcription factors. It acts as a transcriptional activator in the nucleus and may contribute to the development of mesenchymal tissues. Browse Assay Genie's current range of FOXC2 research reagents below, or read on for the biology behind the target.
FOXC2 is a transcription factor that functions as a transcriptional activator. Like other members of the forkhead family, it is characterised by a distinct DNA-binding forkhead domain, which allows it to engage DNA and regulate gene expression. The FOXC2 protein is located in the nucleus, consistent with this role.
The specific function of the FOXC2 gene has not yet been fully determined. The NCBI Gene summary notes, however, that it may play a role in the development of mesenchymal tissues. This makes the FOXC2 protein a point of interest for researchers studying how transcriptional regulation shapes tissue formation. The human protein is encoded on chromosome 16 and is listed by HGNC within the forkhead boxes gene group. Mouse and rat each carry an orthologous gene, Foxc2, so rodent systems are available for comparative work.
The name reflects the gene's history. It was previously designated forkhead box C2 (MFH-1, mesenchyme forkhead 1), and the alias FKHL14 also appears in the literature. The mesenchyme forkhead name echoes the proposed link to mesenchymal development. FOXC1 is a related forkhead box C family member that is often considered alongside FOXC2 when researchers study this part of the forkhead family.
FOXC2 may play a role in the development of mesenchymal tissues, making it a candidate for developmental biology studies.
As a transcriptional activator, FOXC2 is relevant to studies of how forkhead domain proteins control gene expression.
FOXC2 belongs to the forkhead boxes gene group, supporting comparative work across forkhead transcription factors such as FOXC1.
Mouse and rat both carry a Foxc2 ortholog, which allows human and rodent expression and function to be compared.
FOXC2 is a forkhead family transcription factor that acts as a transcriptional activator in the nucleus. Its specific function has not yet been fully determined, but it may play a role in the development of mesenchymal tissues, according to the NCBI Gene summary.
FOXC2 stands for forkhead box C2. It has also been called MFH-1, short for mesenchyme forkhead 1, and FKHL14. These earlier names and symbols may turn up in older publications, so it helps to search with all of them.
Yes. Both mouse and rat have an ortholog named Foxc2, so the gene can be studied in rodent models. Reagent cross-reactivity varies, so check the datasheet of any product for its validated reactivity.
FOXC1, a related forkhead box C family member, and other forkhead transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99958; product specifications from Assay Genie datasheets.