DOCK4
DOCK4 (dedicator of cytokinesis 4) is a member of the DOCK family of Rho guanine nucleotide exchange factors, also known as KIAA0716 and FLJ34238. It is a membrane-associated, cytoplasmic protein involved in regulating adherens junctions between cells. Browse Assay Genie's current range of DOCK4 research reagents below, or read on for the biology behind the target.
DOCK4 functions as a guanine nucleotide exchange factor (GEF). It belongs to the DOCK family, which HGNC classes among the Rho GEFs. NCBI Gene reports that the protein is involved in regulating adherens junctions between cells. UniProt notes that the annotated isoform has a higher guanine nucleotide exchange factor activity than other isoforms, so isoform identity matters when interpreting experimental results.
The DOCK4 gene encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain, which is why HGNC also lists it in the SH3 domain containing group. The DOCK4 protein is described as membrane-associated and cytoplasmic. UniProt records its subcellular locations as the cell membrane, cell projections and the cytosol. Alternatively spliced variants encoding different protein isoforms have been described, although only one has been fully characterised.
Mutations in DOCK4 have been associated with ovarian, prostate, glioma and colorectal cancers, which makes it a gene of interest in cancer biology and in studies of cell-cell adhesion. The gene has also been catalogued under the aliases KIAA0716 and FLJ34238. The mouse ortholog is Dock4, and related family members include DOCK1 and DOCK2.
As a DOCK family guanine nucleotide exchange factor, DOCK4 is relevant to studies of how Rho-family signalling is activated.
DOCK4 is involved in regulating adherens junctions between cells, making it a target for work on junction integrity.
Mutations in DOCK4 have been associated with ovarian, prostate, glioma and colorectal cancers.
Alternatively spliced DOCK4 variants exist, and one isoform shows higher exchange factor activity than others.
DOCK4 acts as a guanine nucleotide exchange factor and is involved in regulating adherens junctions between cells. It is a membrane-associated, cytoplasmic protein containing DHR-1, DHR-2 and SH3 domains, and it belongs to the DOCK family.
DOCK4 stands for dedicator of cytokinesis 4. Aliases include KIAA0716 and FLJ34238. Alternatively spliced variants encoding different isoforms have been described, but only one has been fully characterised. UniProt notes that one isoform has higher exchange factor activity than the others.
Mutations in DOCK4 have been associated with ovarian, prostate, glioma and colorectal cancers. A mouse ortholog, Dock4, exists. Check the datasheet of any product for its validated reactivity.
Other DOCK family Rho guanine nucleotide exchange factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8N1I0; product specifications from Assay Genie datasheets.