MPP2
MPP2 (MAGUK p55 scaffold protein 2) is a postsynaptic scaffold protein of the MAGUK family that links cell adhesion molecules to the postsynaptic density. It is also known as DLG2 or DKFZp761D0712, and was previously named membrane palmitoylated protein 2. Browse Assay Genie's current range of MPP2 research reagents below, or read on for the biology behind the target.
MPP2 is a postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons it is required for the function of synaptic KCNN2-containing channels and for the expression of long-term potentiation. In epithelial cells it seems to negatively regulate SRC function.
The MPP2 gene encodes a member of the membrane-associated guanylate kinase homologs, or MAGUKs. As a group, MAGUKs interact with the cytoskeleton and regulate cell proliferation, signalling pathways and intracellular junctions. The protein contains an SH3 (src homology 3) motif, a sequence found in several other cytoskeleton-associated proteins that are suspected to play important roles in signal transduction. HGNC classes MPP2 among the membrane associated guanylate kinases, with PDZ domain and SH3 domain containing proteins. UniProt records the MPP2 protein in the cytoplasmic cytoskeleton, at the membrane, in dendrites and at the postsynaptic density.
The protein was previously named membrane protein, palmitoylated 2, and is also called membrane palmitoylated protein 2 and palmitoylated membrane protein 2. DLG2 is listed as an alias. Orthologous genes are annotated in mouse and rat, both named Mpp2, which allows the MPP2 gene to be studied in rodent models of synaptic function.
MPP2 connects CADM1 adhesion molecules to the postsynaptic density, making it a useful target for studying how synaptic protein complexes are organised.
In CA1 pyramidal neurons, MPP2 is required for long-term potentiation expression, linking the scaffold to mechanisms of synaptic plasticity.
MPP2 is required for synaptic KCNN2-containing channel function, so it is relevant to research on how scaffolds support channel activity at synapses.
MPP2 seems to negatively regulate SRC function in epithelial cells, which makes it of interest in signal transduction and cell junction studies.
MPP2 is a postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density. In CA1 pyramidal neurons it is required for KCNN2-containing channel function and long-term potentiation expression, and it seems to negatively regulate SRC in epithelial cells.
MPP2 stands for MAGUK p55 scaffold protein 2. UniProt calls it MAGUK p55 subfamily member 2. Aliases include DLG2 and DKFZp761D0712, and earlier names include membrane protein, palmitoylated 2 and membrane palmitoylated protein 2.
Yes. Mouse and rat both carry an ortholog named Mpp2. The protein belongs to the MAGUK family, whose members interact with the cytoskeleton and regulate signalling and intracellular junctions. Check the datasheet of any product for its validated reactivity.
Other MAGUK scaffold proteins, postsynaptic density components and signalling partners related to MPP2 research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q14168; product specifications from Assay Genie datasheets.