MTX1
MTX1 (metaxin 1, also known as MTXN and MTX) is a mitochondrial outer membrane protein involved in the transport of proteins into the mitochondrion. It belongs to the metaxin family and is essential for embryonic development. Browse Assay Genie's current range of MTX1 research reagents below, or read on for the biology behind the target.
MTX1 is involved in the transport of proteins into the mitochondrion. According to NCBI Gene, it is predicted to take part in assembly of the mitochondrial outer membrane translocase complex and in the insertion of proteins into the mitochondrial outer membrane. The protein is a membrane component located in the mitochondrion, specifically in the outer membrane, where protein import machinery operates.
The MTX1 protein is described as part of two multi-subunit assemblies: the MIB complex and the SAM complex. This places it among the factors that organise the mitochondrial outer membrane and support the sorting of proteins into it. UniProt also records that MTX1 is essential for embryonic development, which makes it a useful subject for studies of mitochondrial biogenesis and early development. A mouse ortholog, Mtx1, is recognised, so the MTX1 gene can be examined in mouse models as well as in human systems.
MTX1 is the founding member of the metaxins, a gene group that HGNC lists under the name Metaxins. The family also includes MTX2 and MTX3, which are worth considering alongside MTX1 when studying outer membrane protein import. Symbols seen in the literature include MTXN and MTX, which are previous or alternative designations for the same gene. Researchers working on mitochondrial import, outer membrane complex assembly or developmental biology will find MTX1 a relevant target, whether they are looking for an MTX1 antibody, an MTX1 ELISA kit or recombinant MTX1 protein.
MTX1 is involved in transporting proteins into the mitochondrion, making it relevant to studies of how precursor proteins reach this organelle.
MTX1 is predicted to contribute to assembly of the mitochondrial outer membrane translocase complex and to protein insertion into the outer membrane.
MTX1 is part of both the SAM complex and the MIB complex, so it is studied in work on outer membrane protein machinery.
UniProt describes MTX1 as essential for embryonic development, linking mitochondrial import function to early developmental processes.
MTX1 is involved in the transport of proteins into the mitochondrion. It is predicted to participate in assembling the mitochondrial outer membrane translocase complex and inserting proteins into the outer membrane. It is part of the MIB and SAM complexes and is essential for embryonic development.
MTX1 is the approved HGNC symbol for metaxin 1. The protein is named Metaxin-1 in UniProt, and the gene has also been referred to as MTXN and MTX. These names describe the same human gene, which sits in the Metaxins gene group.
A mouse ortholog, Mtx1, is recognised. MTX1 belongs to the metaxin family, which also includes MTX2 and MTX3. Check the datasheet of any product for its validated reactivity before using it in a particular species.
Other metaxin family members involved in mitochondrial outer membrane protein import.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13505; product specifications from Assay Genie datasheets.