GPRC5D
GPRC5D is a G protein-coupled receptor of the class C orphan group, located at the cell membrane. UniProt annotates it as involved in hard keratin expression and likely in the development of hair and nails. Browse Assay Genie's current range of GPRC5D research reagents below, or read on for the biology behind the target.
GPRC5D (G protein-coupled receptor class C group 5 member D) is a G protein-coupled receptor that localises to the cell membrane. According to UniProt, it is involved in hard keratin expression and likely plays a role in the development of hair and nails. The NCBI Gene summary is more cautious: it places the encoded protein in the G protein-coupled receptor family but notes that the specific function of the gene has not yet been determined. Researchers studying this receptor should therefore treat its biology as still under investigation.
The GPRC5D gene encodes a protein that belongs to the G protein-coupled receptor 3 family. HGNC classifies it within the class C orphans, a group of G protein-coupled receptors for which no ligand has been assigned in the nomenclature. The gene sits at 12p13.1 in the human genome, and a mouse ortholog, Gprc5d, is recorded. A GPRC5D antibody, GPRC5D ELISA kit or recombinant GPRC5D protein can be used to examine the receptor in these settings.
The gene has carried several names. Earlier HGNC entries read G protein-coupled receptor, family C, group 5, member D, and G protein-coupled receptor, class C, group 5, member D. All describe the same locus. GPRC5D is also a close relative of GPRC5A in the group 5 subfamily naming, which is useful context when comparing receptors of this type.
GPRC5D is a class C orphan receptor whose specific function has not yet been determined, making it a subject for basic receptor characterisation.
UniProt links GPRC5D to hard keratin expression, so it is relevant to studies of keratinised tissue biology.
The receptor likely plays a role in the development of hair and nails, according to its UniProt function annotation.
As a cell membrane G protein-coupled receptor of the GPCR 3 family, GPRC5D is relevant to membrane protein and signalling research.
UniProt describes GPRC5D as a G protein-coupled receptor involved in hard keratin expression that likely plays a role in the development of hair and nails. NCBI notes that its specific function has not yet been determined, so its precise activity remains an open question.
HGNC lists no aliases for GPRC5D. Its previous names were G protein-coupled receptor, family C, group 5, member D, and G protein-coupled receptor, class C, group 5, member D. UniProt names it G protein-coupled receptor family C group 5 member D.
A mouse ortholog, Gprc5d, is recorded for the human gene. GPRC5D belongs to the G protein-coupled receptor 3 family and sits in the HGNC class C orphan group. Check the datasheet of any product for its validated reactivity.
A related group 5 class C G protein-coupled receptor with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NZD1; product specifications from Assay Genie datasheets.