CETP
CETP (cholesteryl ester transfer protein, also known as BPIFF) is a secreted plasma protein that transfers neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. It has a central role in reverse cholesterol transport and lipoprotein remodelling. Browse Assay Genie's current range of CETP research reagents below, or read on for the biology behind the target.
CETP moves neutral lipids between lipoprotein particles in plasma. It allows the net movement of cholesteryl ester from high density lipoproteins (HDL) to triglyceride-rich very low density lipoproteins (VLDL), and the equimolar transport of triglyceride from VLDL to HDL. Through this exchange, the CETP protein regulates reverse cholesterol transport, the process by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.
The CETP gene encodes a protein found in plasma, where it is secreted and acts on circulating lipoproteins. NCBI Gene reports two transcript variants that encode different isoforms. CETP belongs to the BPI/LBP/Plunc superfamily, specifically the BPI/LBP family, and HGNC places it in the BPI fold containing gene group. This relationship is reflected in its alias BPIFF.
Defects in the CETP gene are a cause of hyperalphalipoproteinemia 1 (HALP1), which links the protein to HDL metabolism in human disease. HGNC previously listed the gene as cholesteryl ester transfer protein, plasma. Because CETP connects HDL and VLDL lipid content, it is a common subject in studies of lipoprotein biology, cholesterol transport and lipid metabolism. Researchers working with CETP antibody or CETP ELISA kit formats usually do so to examine the protein in plasma and other lipoprotein-related contexts.
CETP transfers cholesteryl ester and triglyceride among lipoprotein particles, making it central to studies of how HDL and VLDL exchange neutral lipids.
CETP regulates the return of excess cholesterol from peripheral tissues to the liver for elimination, a process studied in cholesterol homeostasis.
Defects in the CETP gene cause hyperalphalipoproteinemia 1 (HALP1), so the protein is relevant to research on inherited variation in HDL levels.
CETP belongs to the BPI/LBP/Plunc superfamily and the BPI fold containing group, supporting comparative work on lipid-binding and transfer proteins.
CETP transfers neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. It moves cholesteryl ester from HDL to triglyceride-rich VLDL and exchanges triglyceride from VLDL to HDL in equimolar amounts, thereby regulating reverse cholesterol transport to the liver.
CETP is also known as BPIFF, and its earlier HGNC name was cholesteryl ester transfer protein, plasma. NCBI Gene reports two transcript variants of the CETP gene that encode different isoforms. Check the datasheet of any product for its validated reactivity.
Yes. According to NCBI Gene, defects in the CETP gene are a cause of hyperalphalipoproteinemia 1 (HALP1). CETP is a secreted plasma protein and belongs to the BPI/LBP family within the BPI/LBP/Plunc superfamily.
Other lipoprotein metabolism and lipid transport targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P11597; product specifications from Assay Genie datasheets.