NPFF
NPFF (neuropeptide FF-amide peptide precursor, also known as FMRFAL) is a secreted precursor of the morphine modulating peptides. It belongs to the FMRFamide related peptide (FARP) family and is processed into several amidated neuropeptides. Browse Assay Genie's current range of NPFF research reagents below, or read on for the biology behind the target.
NPFF encodes the precursor of the morphine modulating peptides. The encoded preproprotein is proteolytically processed to generate multiple amidated peptides, which are secreted. These peptides have wide-ranging physiological effects, including modulation of morphine-induced analgesia, elevation of arterial blood pressure and increased somatostatin secretion from the pancreas. Neuropeptide FF also potentiates and sensitises the acid-sensing ion channels ASIC1 and ASIC3.
The NPFF gene belongs to the HGNC neuropeptides group and to the FARP (FMRFamide related peptide) family. The mouse and rat orthologues are both named Npff. Alternative splicing produces multiple transcript variants, and at least one of them encodes an isoform that is proteolytically processed. The peptides act through receptors such as NPFFR2, which is a useful companion target when studying this signalling system.
In the NCBI Gene summary, the NPFF-derived peptides may play a role in the regulation of heart rate and blood pressure, and in the modulation of morphine-induced antinociception. Patients with hypertension are reported to show decreased expression of the encoded protein. This makes the NPFF protein of interest to researchers working on pain modulation and cardiovascular regulation, and a reference point when designing an NPFF antibody or NPFF ELISA kit experiment.
NPFF peptides modulate morphine-induced analgesia and antinociception, making the precursor relevant to studies of opioid response.
NPFF-derived peptides may regulate heart rate and blood pressure, and hypertensive patients show decreased expression of the encoded protein.
Neuropeptide FF potentiates and sensitises ASIC1 and ASIC3 channels, linking the peptide to acid-sensing channel signalling.
NPFF peptides increase somatostatin secretion from the pancreas, illustrating their wide-ranging physiological effects.
NPFF is processed into amidated morphine modulating peptides. These modulate morphine-induced analgesia, raise arterial blood pressure and increase pancreatic somatostatin secretion. Neuropeptide FF also potentiates and sensitises ASIC1 and ASIC3 channels. Check the datasheet of any product for its validated reactivity.
The HGNC name is neuropeptide FF-amide peptide precursor, and the UniProt name is Pro-FMRFamide-related neuropeptide FF. FMRFAL is an alias. The preproprotein yields multiple amidated peptides, and alternative splicing gives several transcript variants, at least one encoding a processed isoform.
Mouse and rat both carry an orthologous gene named Npff. NCBI Gene reports that patients with hypertension show decreased expression of the encoded protein, and that the peptides may help regulate heart rate and blood pressure.
Receptor partners and other neuropeptide-signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15130; product specifications from Assay Genie datasheets.