TIA1
TIA1 (TIA1 cytotoxic granule associated RNA binding protein, also written TIA-1) is an RNA-binding protein linked to cytotoxic lymphocyte granules. It binds poly(A) homopolymers and has been proposed to contribute to apoptosis induction in cytotoxic lymphocyte targets. Browse Assay Genie's current range of TIA1 research reagents below, or read on for the biology behind the target.
TIA1 is a member of an RNA-binding protein family and is described as possessing nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It preferentially recognises poly(A) homopolymers and induces DNA fragmentation in CTL targets, which has led to the suggestion that the protein may be involved in the induction of apoptosis.
The major granule-associated species is a 15-kDa protein that is thought to derive from the carboxyl terminus of the 40-kDa product by proteolytic processing. The TIA1 gene undergoes alternative splicing, giving rise to different isoforms. UniProt notes that one isoform displays enhanced splicing regulatory activity compared with the TIA isoform Long, so isoform identity matters when interpreting results.
UniProt records TIA1 in the nucleus and the cytoplasm, including stress granules. HGNC classifies the gene within the RNA binding motif containing group. The protein was previously named TIA1 cytotoxic granule-associated RNA-binding protein, and the symbol TIA-1 is also in use. A mouse ortholog, Tia1, is recognised, which is relevant when choosing a model for studying TIA1 antibody, TIA1 protein or TIA1 gene function.
TIA1 is associated with cytotoxic granules and nucleolytic activity against CTL target cells, making it a focus for studies of lymphocyte-mediated killing.
TIA1 recognises poly(A) homopolymers and induces DNA fragmentation in CTL targets, so it is studied as a possible contributor to apoptosis induction.
As a member of an RNA-binding protein family in the RNA binding motif containing group, TIA1 is used to explore RNA recognition.
TIA1 localises to stress granules, and its isoforms differ in splicing regulatory activity, supporting work on RNA processing and isoform function.
TIA1 is an RNA-binding protein that preferentially recognises poly(A) homopolymers. It has nucleolytic activity against cytotoxic lymphocyte target cells and induces DNA fragmentation in them, so it may be involved in apoptosis induction. One isoform shows enhanced splicing regulatory activity compared with the Long isoform.
TIA1 is also written TIA-1, and its former name was TIA1 cytotoxic granule-associated RNA-binding protein. Alternative splicing produces different isoforms. The major granule-associated species is a 15-kDa protein thought to derive from the carboxyl terminus of the 40-kDa product by proteolytic processing.
A mouse ortholog, Tia1, is recognised for the human gene. This supports comparative work in mouse models. Reactivity differs between reagents, so check the datasheet of any product for its validated reactivity.
RNA-binding proteins, apoptosis regulators and cytotoxic lymphocyte markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31483; product specifications from Assay Genie datasheets.