RHOT1
RHOT1 (ras homolog family member T1, also known as MIRO-1, MIRO1 or ARHT1) is an atypical mitochondrial nucleoside-triphosphatase of the outer mitochondrial membrane. It is involved in mitochondrial trafficking and in the control of mitochondrial subcellular distribution. Browse Assay Genie's current range of RHOT1 research reagents below, or read on for the biology behind the target.
RHOT1 is an atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking. It is probably involved in the control of anterograde transport of mitochondria and in their subcellular distribution. The protein can hydrolyse GTP, ATP and UTP, and it promotes mitochondrial fission under high calcium conditions. Gene-level annotation also describes guanyl ribonucleotide binding, metal ion binding and ribonucleoside triphosphate phosphatase activity.
The RHOT1 protein is located in the mitochondrial outer membrane. Annotated processes include mitochondrion transport along microtubule, regulation of mitochondrion organisation and mitochondrial outer membrane permeabilisation. These roles make RHOT1 a useful point of reference when studying how mitochondria are positioned and remodelled within the cell.
RHOT1 belongs to the mitochondrial Rho GTPase family. HGNC places it in the group of Miro like atypical Rho GTPases, which is also classed as EF-hand domain containing. The official name is ras homolog family member T1, and the gene was previously called ras homolog gene family, member T1. Other names in use include MIRO-1, MIRO1, ARHT1 and FLJ11040. Orthologous genes, both named Rhot1, are found in mouse and rat, so the RHOT1 gene can be studied in common rodent models.
RHOT1 is involved in mitochondrial trafficking and probably in anterograde transport, so it is studied in work on how mitochondria are moved and distributed.
RHOT1 promotes mitochondrial fission under high calcium conditions, linking it to research on calcium-dependent control of mitochondrial organisation.
Annotated with mitochondrion transport along microtubule, RHOT1 is a relevant target for studying how organelles are carried along the cytoskeleton.
RHOT1 hydrolyses GTP, ATP and UTP, making it of interest for studying nucleotide handling by atypical Rho family GTPases.
RHOT1 is an atypical mitochondrial NTPase involved in mitochondrial trafficking. It is probably involved in controlling anterograde transport of mitochondria and their subcellular distribution. It promotes mitochondrial fission during high calcium conditions and can hydrolyse GTP, ATP and UTP.
RHOT1 is also called MIRO-1, MIRO1, ARHT1 and FLJ11040. UniProt lists the protein as mitochondrial Rho GTPase 1, while HGNC uses ras homolog family member T1, previously ras homolog gene family, member T1. Searching by any of these names may help when reviewing literature.
Yes. Both mouse and rat have an ortholog named Rhot1, so rodent models can be used to study the gene. RHOT1 belongs to the mitochondrial Rho GTPase family; check the datasheet of any product for its validated reactivity.
Other mitochondrial Rho GTPases, mitochondrial dynamics regulators and trafficking proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8IXI2; product specifications from Assay Genie datasheets.