ABHD4
ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) is a member of the abhydrolase domain containing gene group, predicted to act on phospholipids and in the handling of N-acylated lipids. It was previously listed under the alias FLJ12816. Browse Assay Genie's current range of ABHD4 research reagents below, or read on for the biology behind the target.
ABHD4 is predicted to enable lysophosphatidic acid acyltransferase activity and phosphatidylcholine lysophospholipase A1 activity. These predicted activities place the ABHD4 protein within phospholipid metabolism, where acyl groups are added to or removed from lysophospholipid and phospholipid substrates. The assignments come from computational prediction rather than direct experimental annotation, so they are best read as a working framework for study.
In terms of biological process, ABHD4 is predicted to be involved in the N-acylphosphatidylethanolamine metabolic process, lipid homeostasis and phosphatidic acid biosynthesis. It is also predicted to act upstream of or within the N-acylethanolamine metabolic process. Together these annotations suggest a role in the pathways that generate and process N-acylated phospholipids and related lipid species.
For localisation, ABHD4 is predicted to be located in the endoplasmic reticulum membrane and to be active in lipid droplets, both compartments central to lipid synthesis and storage. The ABHD4 gene is a member of the abhydrolase domain containing group, and its HGNC name, abhydrolase domain containing 4, N-acyl phospholipase B, reflects its proposed enzymatic function. The mouse ortholog is Abhd4. Other ABHD genes, such as ABHD5 and ABHD6, belong to the same gene group and are often studied alongside it.
ABHD4 is predicted to have lysophosphatidic acid acyltransferase and phosphatidylcholine lysophospholipase A1 activity, making it a candidate for studies of phospholipid remodelling.
The gene is predicted to act in N-acylphosphatidylethanolamine and N-acylethanolamine metabolic processes, relevant to research on N-acylated lipid handling.
ABHD4 is predicted to contribute to lipid homeostasis and phosphatidic acid biosynthesis, supporting work on how cells balance lipid species.
Predicted localisation to the endoplasmic reticulum membrane and activity in lipid droplets make ABHD4 relevant to studies of lipid-handling compartments.
ABHD4 is predicted to enable lysophosphatidic acid acyltransferase and phosphatidylcholine lysophospholipase A1 activity. It is predicted to be involved in N-acylphosphatidylethanolamine metabolism, lipid homeostasis and phosphatidic acid biosynthesis. These functions are predictions, not experimentally confirmed annotations.
The HGNC full name is abhydrolase domain containing 4, N-acyl phospholipase B. The earlier name was abhydrolase domain containing 4, and FLJ12816 is listed as an alias or previous symbol. The gene is in the abhydrolase domain containing gene group.
A mouse ortholog, Abhd4, is recorded for the human gene. No rat ortholog is given in the data available here. Researchers should check the datasheet of any product for its validated reactivity before choosing a model system.