PDE10A
PDE10A (phosphodiesterase 10A) is a dual-substrate cyclic nucleotide phosphodiesterase that regulates intracellular cAMP and cGMP concentrations. It belongs to the cyclic nucleotide phosphodiesterase family and is thought to be important for cyclic nucleotide signalling in the striatum of the brain. Browse Assay Genie's current range of PDE10A research reagents below, or read on for the biology behind the target.
PDE10A plays a role in signal transduction by controlling the intracellular concentration of cyclic nucleotides. The enzyme can hydrolyse both cAMP and cGMP, converting them to the corresponding nucleoside 5' monophosphate. It has a higher affinity for cAMP and is more efficient with cAMP as its substrate, so it is often described as a cAMP-preferring enzyme that also acts on cGMP. Its UniProt protein name, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, reflects this dual-substrate behaviour.
The PDE10A gene encodes a protein that localises to the cytosol and belongs to the cyclic nucleotide phosphodiesterase family. HGNC classifies it in the phosphodiesterase gene group. Alternatively spliced transcript variants have been described for the gene. Orthologues are annotated in mouse and rat, both named Pde10a, which allows the protein to be studied in common rodent models.
Functionally, PDE10A may play a critical role in regulating cAMP and cGMP levels in the striatum, a brain region that contributes to the control of movement and cognition. This makes the enzyme a point of interest for researchers studying cyclic nucleotide signalling in striatal circuits. Researchers working with the PDE10A protein, whether through an antibody, an ELISA kit or gene-level analysis, can use these properties to frame their experiments on how cyclic nucleotide turnover shapes cellular signalling.
PDE10A hydrolyses both cAMP and cGMP, making it a useful enzyme for studying how intracellular cyclic nucleotide levels are controlled in signal transduction.
PDE10A may regulate cAMP and cGMP levels in the striatum, a brain region that contributes to the control of movement and cognition.
The enzyme has higher affinity and efficiency for cAMP than cGMP, offering a model for comparing substrate preference within the phosphodiesterase family.
As a member of the cyclic nucleotide phosphodiesterase family, PDE10A can be studied alongside other PDEs to compare roles in cyclic nucleotide regulation.
PDE10A regulates the intracellular concentration of cyclic nucleotides by hydrolysing both cAMP and cGMP. It has higher affinity for cAMP and is more efficient with it as substrate. It may play a critical role in controlling cAMP and cGMP levels in the striatum.
The HGNC name is phosphodiesterase 10A, and UniProt names the protein cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A. No alternative symbols are listed. Alternatively spliced transcript variants have been described for the gene, so check the datasheet of any product for its validated reactivity.
Yes. Orthologues of the human gene are annotated in both mouse and rat, and each is named Pde10a. This allows PDE10A to be studied in rodent systems, but check the datasheet of any product for its validated reactivity.
Other phosphodiesterases involved in cAMP and cGMP regulation with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y233; product specifications from Assay Genie datasheets.