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ABHD14A
ABHD14A (abhydrolase domain containing 14A) is a member of the AB hydrolase superfamily and the ABHD14 family, predicted to have hydrolase activity. It is also known as DKFZP564O243 and DORZ1, and has a possible role in granule neuron development. Browse Assay Genie's current range of ABHD14A research reagents below, or read on for the biology behind the target.
ABHD14A is predicted to enable hydrolase activity, consistent with its place in the AB hydrolase superfamily. Its enzyme classification is given only at the general level of EC 3.-.-.-, so its substrates and precise catalytic reaction are not defined in the sources used here. UniProt annotates a possible role in granule neuron development, though the mechanism is not described.
The protein is annotated as belonging to the ABHD14 family, and HGNC places the gene in the abhydrolase domain containing group. Predictions from the Alliance of Genome Resources indicate that ABHD14A is located in the membrane and is active in the cytoplasm, in line with the UniProt subcellular locations of cytoplasm and membrane. Orthologues are recognised in mouse and rat, both named Abhd14a, which allows the ABHD14A gene to be studied in common rodent models.
The gene symbol ABHD14A is approved by HGNC, and the gene has also been reported as DKFZP564O243 and DORZ1. Within the wider ABHD group, related proteins such as ABHD14B, ABHD11, ABHD2, ABHD4, ABHD5 and ABHD6 are useful comparators when characterising the function of this less well-defined member. Researchers working with ABHD14A will often use it alongside these relatives to place its activity in context.
ABHD14A is predicted to have hydrolase activity, so its substrates and catalytic function remain open questions for enzymology.
UniProt notes a possible role in granule neuron development, making ABHD14A a candidate for developmental neuroscience studies.
As an ABHD14 family member, ABHD14A supports comparative work across the AB hydrolase superfamily and its paralogues.
Predicted cytoplasmic and membrane association makes ABHD14A relevant to studies of where putative hydrolases act within the cell.
ABHD14A is predicted to enable hydrolase activity and belongs to the AB hydrolase superfamily. UniProt describes a possible role in granule neuron development. Its specific substrates and reactions are not defined in the available annotation, so its function is still largely inferred.
The HGNC full name is abhydrolase domain containing 14A, and UniProt lists it as Protein ABHD14A. Other names and previous symbols include DKFZP564O243 and DORZ1. It belongs to the ABHD14 family, alongside ABHD14B.
Yes. Both mouse and rat have an orthologue named Abhd14a, so rodent models can be used to study the gene. Check the datasheet of any product for its validated reactivity before choosing a species.
Other abhydrolase domain containing proteins and AB hydrolase superfamily members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BUJ0; product specifications from Assay Genie datasheets.
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