There are no products listed under this category.
HIPK4
HIPK4 (homeodomain interacting protein kinase 4) is a serine/threonine protein kinase of the HIPK family. It phosphorylates the tumour suppressor TP53 and may act as a transcriptional corepressor; the gene was previously listed as FLJ32818. Browse Assay Genie's current range of HIPK4 research reagents below, or read on for the biology behind the target.
HIPK4 is a protein kinase that phosphorylates human TP53 at Ser-9. Through this modification it induces TP53-mediated repression of the BIRC5 promoter. UniProt also notes that HIPK4 may act as a corepressor of transcription factors, although this is annotated as potential rather than established. The protein is a serine/threonine kinase (EC 2.7.11.1) and is located in the cytoplasm.
The HIPK4 gene encodes a member of the homeodomain interacting protein kinase family. It belongs to the protein kinase superfamily, the CMGC Ser/Thr protein kinase family and the HIPK subfamily. According to the NCBI Gene summary, other HIPK family members are found throughout vertebrates, whereas HIPK4 is present only in mammals. Compared with the other family members, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. Mouse and rat both have a Hipk4 ortholog.
The HIPK4 protein exhibits kinase activity and may phosphorylate the tumour suppressor p53. This link to TP53 and to repression of the BIRC5 promoter makes it a point of interest for researchers studying p53 regulation and kinase signalling. Related family members include HIPK1 and HIPK2, which are useful comparators when examining what is distinctive about HIPK4.
HIPK4 phosphorylates TP53 at Ser-9, making it relevant to studies of how post-translational modification shapes p53 activity.
Phosphorylated TP53 represses the BIRC5 promoter, and HIPK4 may also act as a corepressor of transcription factors.
HIPK4 lacks a nuclear localization signal and a C-terminal autoinhibitory domain, setting it apart from other HIPK family members.
Unlike other HIPK kinases found throughout vertebrates, HIPK4 is present only in mammals, which suits comparative studies.
HIPK4 is a protein kinase that phosphorylates human TP53 at Ser-9, which induces TP53 repression of the BIRC5 promoter. It may also act as a corepressor of transcription factors, although this is annotated as potential. It is located in the cytoplasm.
HIPK4 stands for homeodomain interacting protein kinase 4, and its UniProt name is Homeodomain-interacting protein kinase 4. The alias FLJ32818 is also recorded. It is a member of the HIPK family and the CMGC Ser/Thr protein kinase group (EC 2.7.11.1).
Unlike other HIPK family members, which occur throughout vertebrates, HIPK4 is present only in mammals. Mouse and rat each have a Hipk4 ortholog. Check the datasheet of any product for its validated reactivity.
Other members of the homeodomain interacting protein kinase family with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8NE63; product specifications from Assay Genie datasheets.
There are no products listed under this category.