HDGFL3
HDGFL3 (HDGF like 3, also known as HRP-3 and Hdgfrp3) is a nuclear member of the HDGF family. It enhances DNA synthesis and may play a role in cell proliferation. Browse Assay Genie's current range of HDGFL3 research reagents below, or read on for the biology behind the target.
HDGFL3 is a member of the HDGF family. According to UniProt, the protein enhances DNA synthesis and may play a role in cell proliferation. It is annotated as a nuclear protein, and NCBI Gene reports that it is located in the nucleoplasm.
The NCBI Gene summary, based on Alliance of Genome Resources predictions, adds a cytoskeletal dimension. HDGFL3 is predicted to enable microtubule binding activity and to be involved in microtubule polymerisation, negative regulation of microtubule depolymerisation and neuron projection development. These roles are predicted rather than experimentally established, so they are best treated as hypotheses to test.
The HDGFL3 gene is classified by HGNC in the heparin binding growth factor family, and the full protein name is hepatoma-derived growth factor-related protein 3. The aliases HRP-3 and Hdgfrp3 appear in older literature. Orthologues of the gene are named Hdgfl3 in both mouse and rat, which allows the protein to be studied in rodent models. A related family member, HDGFL2, is a useful comparator when examining shared and distinct functions within the HDGF family.
HDGFL3 is reported to enhance DNA synthesis and may play a role in cell proliferation, making it relevant to growth control research.
The protein is predicted to bind microtubules and to influence their polymerisation and depolymerisation, which invites study of microtubule dynamics.
HDGFL3 is predicted to be involved in neuron projection development, pointing to a possible role in neuronal morphology.
As an HDGF family member, HDGFL3 supports comparative work on how related nuclear proteins differ in function and localisation.
UniProt reports that HDGFL3 enhances DNA synthesis and may play a role in cell proliferation. NCBI Gene also predicts that it binds microtubules, contributes to microtubule polymerisation and neuron projection development, and is located in the nucleoplasm.
HDGFL3 stands for HDGF like 3. Its UniProt protein name is hepatoma-derived growth factor-related protein 3, and aliases include HRP-3 and Hdgfrp3. All of these names refer to the same gene and protein product.
Yes. The mouse and rat orthologues are both named Hdgfl3. The protein belongs to the HDGF family, which also includes HDGFL2. Check the datasheet of any product for its validated reactivity.
Other HDGF family members and related nuclear proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y3E1; product specifications from Assay Genie datasheets.