RHOC
RHOC (ras homolog family member C, also known as ARH9 or ARHC) is a Rho family small GTPase that acts as a molecular switch in signal transduction. It links plasma membrane receptors to actin cytoskeleton organisation, cell shape and motility. Browse Assay Genie's current range of RHOC research reagents below, or read on for the biology behind the target.
RHOC belongs to the small GTPase superfamily and the Rho family. Like other Rho proteins, it cycles between an inactive GDP-bound state and an active GTP-bound state, and in this way functions as a molecular switch in signal transduction cascades. Rho proteins promote reorganisation of the actin cytoskeleton and regulate cell shape, attachment and motility. RHOC regulates a signalling pathway that links plasma membrane receptors to the assembly of focal adhesions and actin stress fibres.
During the cell cycle, RHOC serves as a microtubule-dependent signal required for formation of the myosin contractile ring in cytokinesis, which is consistent with its localisation to the cleavage furrow. It also regulates apical junction formation in bronchial epithelial cells. The RHOC protein is prenylated at its C-terminus and localises to the cytoplasm and plasma membrane, and it is thought to be important in cell locomotion.
The RHOC gene is classed by HGNC in the Rho family GTPases group, and its previous name was ras homolog gene family, member C. Multiple alternatively spliced transcript variants have been identified, all encoding the same protein. Overexpression of the gene is associated with tumour cell proliferation and metastasis, which makes RHOC a frequent subject in studies of cell migration and cancer progression. A mouse ortholog, Rhoc, is recorded.
RHOC overexpression is associated with tumour cell proliferation and metastasis, making it a focus for studies of invasive behaviour.
Rho proteins regulate cell shape, attachment and motility, and RHOC is thought to be important in cell locomotion.
RHOC regulates signalling that leads to focal adhesion and actin stress fibre assembly downstream of membrane receptors.
RHOC acts as a microtubule-dependent signal needed for myosin contractile ring formation during cytokinesis.
RHOC is a Rho family small GTPase that switches between GDP-bound and GTP-bound states. It regulates signalling from plasma membrane receptors to focal adhesions and actin stress fibres, supports myosin contractile ring formation in cytokinesis, and regulates apical junction formation in bronchial epithelial cells.
RHOC is also known as ARH9 and ARHC. The full name is ras homolog family member C, previously ras homolog gene family, member C. UniProt names the protein Rho-related GTP-binding protein RhoC. Alternatively spliced variants of the RHOC gene all encode the same protein.
According to NCBI Gene, overexpression of RHOC is associated with tumour cell proliferation and metastasis. A mouse ortholog, Rhoc, exists, so the gene can be studied in mouse models; check the datasheet of any product for its validated reactivity.
Other Rho family GTPases, cytoskeleton regulators and cell motility markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08134; product specifications from Assay Genie datasheets.