CAV2
CAV2 (caveolin 2, also known as CAV) is a member of the caveolin family and a major component of the inner surface of caveolae. It acts as an accessory partner to CAV1 in caveolae formation and is linked to signal transduction and growth control. Browse Assay Genie's current range of CAV2 research reagents below, or read on for the biology behind the target.
CAV2 may act as a scaffolding protein within caveolar membranes. It interacts directly with G protein alpha subunits and can functionally regulate their activity. Together with CAV1, it acts as an accessory protein in targeting to lipid rafts and in driving caveolae formation. The NCBI Gene summary describes the protein as a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and links it to signal transduction, lipid metabolism, cellular growth control and apoptosis.
CAV2 is also connected to mitogenic signalling. It is a positive regulator of cellular mitogenesis through the MAPK signalling pathway, and it is required for insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, with subsequent regulation of cell cycle progression. The form phosphorylated at Ser-36 has a role in modulating mitosis in endothelial cells. The protein has been reported in the nucleus, cytoplasm, Golgi apparatus membrane, cell membrane and caveolae. This protein may function as a tumour suppressor.
The CAV2 gene belongs to the caveolin family and lies next to its relative CAV1 on chromosome 7. The two genes express colocalising proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encode different isoforms, and further isoforms arise from alternate in-frame translation initiation codons, which show preferential localisation within the cell. Mouse and rat both have a Cav2 ortholog.
CAV2 works with CAV1 in lipid raft targeting and caveolae formation, making it relevant to studies of caveolar membrane organisation.
CAV2 interacts directly with G protein alpha subunits and can regulate their activity, a link used in studies of membrane signal transduction.
CAV2 is required for insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, tying it to mitogenic signalling and cell cycle control.
CAV2 may function as a tumour suppressor and is involved in growth control and apoptosis, and Ser-36 phosphorylation modulates endothelial mitosis.
CAV2 may act as a scaffolding protein in caveolar membranes. It interacts with G protein alpha subunits, helps CAV1 drive caveolae formation, and positively regulates MAPK-dependent mitogenesis. It is also required for insulin-stimulated nuclear translocation of MAPK1 and STAT3 and for cell cycle progression.
The HGNC-approved name is caveolin 2, and CAV is listed as an alias. UniProt calls the protein Caveolin-2. Alternatively spliced transcript variants encode different isoforms, and alternate in-frame translation initiation codons give further isoforms with preferential localisation in the cell.
CAV2 and CAV1 are neighbouring genes on chromosome 7. Their colocalising proteins form a stable hetero-oligomeric complex, and CAV2 helps CAV1 target lipid rafts and form caveolae. Mouse and rat each have a Cav2 ortholog; check the datasheet of any product for its validated reactivity.
Other caveolins and caveolae-associated proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P51636; product specifications from Assay Genie datasheets.