PPARGC1A
PPARGC1A (PPARG coactivator 1 alpha, also known as PGC-1alpha, PGC1A and PGC1) is a transcriptional coactivator for nuclear and steroid receptors. It regulates genes involved in energy metabolism and links external physiological stimuli to mitochondrial biogenesis. Browse Assay Genie's current range of PPARGC1A research reagents below, or read on for the biology behind the target.
PPARGC1A is a transcriptional coactivator for steroid receptors and nuclear receptors. It greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter, and it can regulate key mitochondrial genes that contribute to adaptive thermogenesis. It also interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Interaction with PPARgamma permits it to engage multiple transcription factors.
The protein coordinates the expression of a wide array of genes involved in glucose and fatty acid metabolism, and so plays an essential role in metabolic reprogramming in response to dietary availability. It is a key regulator of gluconeogenesis. It stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and it acts together with FOXO1 to promote the fasting gluconeogenic program. In skeletal muscle it induces PERM1 expression in an ESRRA-dependent manner, and it is a major factor in muscle fibre type determination.
PPARGC1A also integrates circadian rhythms with energy metabolism. Through coactivation of RORA and RORC, it is required for oscillatory expression of clock genes such as BMAL1 and NR1D1, and of metabolic genes such as PDK4 and PEPCK. The NCBI Gene summary notes possible roles in controlling blood pressure, regulating cellular cholesterol homoeostasis and the development of obesity. UniProt places the protein in the nucleus, including PML bodies, and in the cytoplasm. HGNC lists the gene as PPARG coactivator 1 alpha, with earlier names that include peroxisome proliferative activated receptor, gamma, coactivator 1, alpha. Mouse and rat both carry a Ppargc1a ortholog.
PPARGC1A provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, making it a central focus in mitochondrial research.
It coordinates genes of glucose and fatty acid metabolism and drives the fasting gluconeogenic program together with FOXO1.
PPARGC1A boosts PPARG and thyroid hormone receptor activity on the uncoupling protein promoter and regulates mitochondrial genes behind adaptive thermogenesis.
It is required for oscillatory clock gene expression through RORA and RORC, and it helps determine muscle fibre type.
PPARGC1A is a transcriptional coactivator that regulates genes of energy metabolism. It enhances nuclear receptor activity, promotes mitochondrial biogenesis and adaptive thermogenesis, and stimulates hepatic gluconeogenesis with FOXO1. It also supports circadian clock gene expression through RORA and RORC.
PPARGC1A is widely called PGC-1alpha. Other aliases and earlier symbols include PGC1, PGC1A, PPARAGCIα and PPARGC1. The gene was previously named peroxisome proliferative activated receptor, gamma, coactivator 1, alpha. Searching under any of these names should find the same target.
Yes. Mouse and rat both have a Ppargc1a gene orthologous to human PPARGC1A. Researchers studying metabolism in rodent models can therefore work with the equivalent gene, but check the datasheet of any product for its validated reactivity.
A related PGC-1 family coactivator with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UBK2; product specifications from Assay Genie datasheets.