LRP11
LRP11 (low-density lipoprotein receptor-related protein 11, also known as MANSC3 and bA350J20.3) is a membrane protein that belongs to the LDLR family. It is reported to bind phosphoproteins, and its biology is still being characterised. Browse Assay Genie's current range of LRP11 research reagents below, or read on for the biology behind the target.
LRP11 is a member of the LDLR family and is classed by HGNC in the low density lipoprotein receptors gene group. According to NCBI Gene, the LRP11 protein enables phosphoprotein binding activity and is predicted to be located in the plasma membrane. UniProt lists its subcellular location as membrane. No curated functional annotation is currently provided by UniProt, so the detailed molecular mechanism of LRP11 remains to be established.
NCBI Gene also reports that LRP11 is predicted to be involved in several processes, including response to cold, response to heat and response to water deprivation. These assignments are predictions from the Alliance of Genome Resources rather than experimentally defined roles, and researchers should treat them as starting hypotheses for functional work on the LRP11 protein.
The human LRP11 gene is also known by the alias MANSC3 and by the clone-derived name bA350J20.3. Its approved name, LDL receptor related protein 11, was previously written as low density lipoprotein receptor-related protein 11. The mouse ortholog is Lrp11, which allows comparative studies in a common model organism. As with other LDLR family members, LRP11 is often studied alongside related receptors such as LRP1, LRP2 and LRP12 when researchers want to place it within the wider family.
LRP11 belongs to the LDLR family, making it a candidate for comparative studies across low density lipoprotein receptor-related proteins.
LRP11 is a membrane protein predicted to sit at the plasma membrane, so its localisation and topology are open questions.
NCBI Gene reports that LRP11 enables phosphoprotein binding, which points to interaction studies with phosphorylated partners.
LRP11 is predicted to be involved in responses to cold, heat and water deprivation, a hypothesis that merits experimental testing.
The function of LRP11 is not yet well defined. NCBI Gene reports that it enables phosphoprotein binding activity and is predicted to be located in the plasma membrane. It is also predicted to take part in responses to cold, heat and water deprivation.
LRP11 is the approved symbol for low-density lipoprotein receptor-related protein 11. The gene has also been called MANSC3 and bA350J20.3. HGNC records the earlier name as low density lipoprotein receptor-related protein 11, and the protein is listed in UniProt under Q86VZ4.
A mouse ortholog, Lrp11, is recorded for the human gene, so mouse models and reagents can be considered for comparative work. No rat ortholog is listed in the data used here. Check the datasheet of any product for its validated reactivity.
Other LDL receptor related proteins and associated factors that sit alongside LRP11 in the LDLR family.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q86VZ4; product specifications from Assay Genie datasheets.